29 results
Ophthalmoplegia secondary to Orbital Apex Syndrome

A 61-year-old man presented with retro-orbital pain, near-complete ophthalmoplegia, loss of
to Orbital Apex Syndrome ... A 61-year-old ... Orbital #Apex #Syndrome ... Ophthalmology #PhysicalExam ... #NEJM
VEXAS (Vacuoles, E1 enzyme, X-linked, Autoinflammatory, Somatic) Syndrome
Clinical Syndrome:
 • Common Clinical Features: alveolitis, ear and
Clinical Syndrome ... Features: alveolitis, ear ... myelodysplastic syndrome ... myeloid cells NEJM ... Autoinflammatory #Somatic #rheumatology
Autoantibodies in Rheumatology
 • Lupus (SLE): ANA (anti-nuclear antibody), dsDNA (double-stranded DNA), Anti-Smith, Anti-Ro (SSA) and
Autoantibodies in Rheumatology ... Antiphospholipid Antibody Syndrome ... LAC) • Sjogren Syndrome ... #diagnosis #associations ... #table
Jaw Clonus on Physical Exam

A 24-year-old man presented with progressive dysphagia, dysarthria, and weakness in his
Physical Exam A 24-year-old ... consistent with a diagnosis ... #Jaw #Clonus #PhysicalExam ... ALS #Neurology #NEJM
Myositis Specific Antibodies (MSAs)

Dermatomyositis: MDA5, TIF1y, NXP2, Mi-2, SAE
Anti-Synthetase Syndrome: Jo-1, PL7, PL12, EJ, OJ
Immune Mediated
Anti-Synthetase Syndrome ... MSAs #clinical #diagnosis ... #rheumatology # ... table
Connective tissue disease-associated interstitial lung diseases

LIP: lymphoid interstitial pneumonia. NSIP: nonspecific interstitial pneumonia. OP: organizing pneumonia.
PSS: Sjogren syndrome ... LungDisease #CTILD #Diagnosis ... Differential #Comparison #Table ... #Pulmonary #Rheumatology
Autoantibodies and their Disease Associations
ANA - Non-specific; common in SLE, autoimmune hepatitis
Anti-CCP, Rheumatoid factor - RA
Anti-dsDNA
Anticentromere - CREST syndrome ... La) - Sjogren's syndrome ... Goodpasture's syndrome ... Associations #diseases #diagnosis ... #table #rheumatology
Thrombocytopenia and Pregnancy - TTP/HUS, HELLP Syndrome and Acute Fatty Liver of Pregnancy (AFLP)
Three syndromes in
TTP/HUS, HELLP Syndrome ... Pregnancy (AFLP) Three syndromes ... AFLP #obstetrics #hematology ... #diagnosis #table
Adie's Pupil
What? Unknown nature & benign
 • Regular and mildly dilated pupil (4-6mm);
 • Light-near dissociaton;
6mm); • Light-near ... Holmes-Adie Syndrome ... females Differential Diagnosis ... - no light-near ... #Adies #Pupil #PhysicalExam
Hyponatremia - Differential Diagnosis by Mechanism
Decr Blood Pressure (“Decr Effective Circulating Volume”) 
 - Volume depletion
- Differential Diagnosis ... - Cirrhosis Syndrome ... potomania - “Tea ... #Differential #Diagnosis ... #Table #Causes