13 results
Algorithm for Investigation of Abnormal Coagulation Tests
- Prolonged PT
- Prolonged aPTT and Prolonged PT
- Prolonged aPTT

Dr.
Investigation of Abnormal ... Coagulation Tests ... #Abnormal #APTT ... #Laboratory #Hematology ... #Diagnosis #Workup
Liver Chemistry Tests - AST, ALT, Alkaline Phosphatase and Bilirubin Metabolism
AST and ALT:
 • AST: liver
Tests - AST, ALT ... #Laboratory #Metabolism ... #ASTALT #AlkPhos ... #Bilirubin #Hepatology ... Pathophysiology #Diagnosis #LFTs
Commonly Observed Laboratory Findings in Hepatic / Liver Failure
 - Elevated conjugated and unconjugated bilirubin -
Commonly Observed Laboratory ... Findings in Hepatic ... deficiency - Anemia ... #LiverFailure #Hepatic ... #Hepatology #Laboratory
Liver Function Tests (LFTs) - Normal Values and Interpretation

Alanine aminotransferase (ALT/SGPT) - Liver, cardiac & skeletal
Liver Function Tests ... (LFTs) - Normal ... #Function #Tests ... #LFTs #Laboratory ... Interpretation #diagnosis #hepatology
Hemolysis - Differential Diagnosis Framework

1) Environment
  - Fragmentation
  - MAHA: TTP, HUS, DIC, HELLP
Defects, Drugs, Liver ... Defects: Sickle cell anemia ... Tests: - Haptoglobin ... Blood Smear ↑ abnormal ... Differential #Diagnosis #hematology
Liver Chemistries - Interpretation of LFTs

R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP)
 • R >
Interpretation of LFTs ... • Albumin • Coagulation ... replaced by non-hepatic ... AST/ALT AST: ... #differential #Hepatology
Causes of Thrombocytopenia and Platelet Disorders - Differential Diagnosis and Workup
History:
 - Prior platelet count, family
Diagnosis and Workup ... changes), high MCV anemia ... gastric bypass), LFT ... (liver disease) ... #hematology
Disseminated Intravascular Coagulation (DIC) Overview

Increased Clotting and Consumption of Clotting Factors

Findings:
 • Bleeding
 • Recent history
dysfunction (25%) • Hepatic ... venipuncture sites Laboratory ... DIC • Severe Liver ... 100mg/dL) - Heparin ... treatment #management #hematology
Bleeding and Bruising - Disorders of Hemostasis - Differential Diagnosis Framework

== Quantitative or Qualitative defect in
inhibitor of a coagulation ... cascade is intact - test ... Acquired: • Heparin ... function tests ... Differential #Diagnosis #Hematology
Acute Liver Injury - Differential Diagnosis Algorithm

Vascular Causes of Acute Liver Injury: 
 • Hepatic vein:
Injury: • Hepatic ... extrahepatic source - Tests ... function may be abnormal ... AST:ALT Ratios ... diagnosis #algorithm #hepatology