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Systemic Sclerosis (Scleroderma) Multi-system autoimmune disease characterized by vasculopathy and progressive fibrosis of skin and internal organs 3
Systemic Sclerosis ... Scleroderma) Multi-system ... LcSSc) - distal skin ... Scleroderma #SSc #rheumatology ... symptoms #testing #workup
Algorithm for Investigation of Abnormal Coagulation Tests - Prolonged PT - Prolonged aPTT and Prolonged PT - Prolonged aPTT Dr.
Abnormal Coagulation Tests ... APTT #Laboratory #Hematology ... #Diagnosis #Workup
Systemic Sclerosis Associated Autoantibodies Anti-topoisomerase I (anti-Sc170): Diffuse skin disease, Pulmonary fibrosis Anti-centromere: Limited skin disease (~93-95%), Pulmonary
Systemic Sclerosis ... anti-Sc170): Diffuse skin ... Rapid progressive skin ... BCM_InternalMed #Systemic ... Autoantibodies #diagnosis #rheumatology
Systemic Lupus Erythematosus - Summary Antinuclear (ANA) - 95% - Initial screening test Anti-dsDNA - 50% • Associated
Systemic Lupus Erythematosus ... Initial screening test ... Associated with skin ... • MCTD (SLE/systemic ... Summary #diagnosis #rheumatology
Approach to the Hypercoagulable State Arterial thromboembolism → Cardiac rhythm monitoring, Echocardiogram, Vascular imaging → Test for APS, particularly
Vascular imaging → Test ... - No other workup ... Hypercoagulable #Workup ... #hematology #diagnosis ... #algorithm #hematology
Pruritus - Generalized Differential Diagnosis Algorithm - Systemic and Primary Causes == Primary Skin Lesions == Macules /
Causes == Primary Skin ... • Xerosis (dry skin ... Lesion / Systemic ... Liver Function Tests ... #generalized #dermatology
Hemolysis - Diagnostic Algorithm and Causes Increased red cell production: • Increased Reticulocytosis/polychromasia • Erythroid
Differential #Causes #Workup ... #Hematology #Diagnosis ... GrepMed Recommended Text
Clinical Features of Systemic Lupus (SLE) General: Fever (50%), Depression, Fatigue (75%), Weight loss (50%) Eye: Sjögrens (15%) Skin
Clinical Features of Systemic ... Sjögrens (15%) Skin ... joints Nervous system ... #Lupus #SLE #systemic ... symptoms #diagnosis #rheumatology
Cold Urticaria Prevalence - 0.05% in the population Disease onset - Mostly 2nd to 4th decades of life Causes
trigger - Direct skin ... 50% of patients Skin ... - Ice cube test ... , TempTest test ... Urticaria #diagnosis #rheumatology
Eosinophil Disorders Testing Algorithm INDICATIONS FOR TESTING: • Peripheral blood eosinophilia/hypereosinophilia uncovered incidentally during medical evaluation or
evaluation or workup ... 1,500 cells/µL Workup ... symptoms (eg, skin ... Differential #diagnosis #hematology
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