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Causes of Metabolic Alkalosis - Differential Diagnosis Chloride depletion syndromes • Gastrointestinal losses -
Chloride depletion syndromes ... Chloruretic drugs (eg, thiazides ... - Bartter syndrome ... - Gitelman syndrome ... • Liddle syndrome
Hypokalemia - Differential Diagnosis Algorithm Extra-renal Losses: • Normal Acid-Base: Low intake • Metabolic acidosis: Gl tract
Aldosterone: Liddle's Syndrome ... SAME, Cushing Syndrome ... Absent: Loop and thiazide ... diuretics, Bartter syndrome ... , Gitelman syndrom
Hypercalcemia - EKG Findings Causes of Hypercalcemia • Malignancy • Milk-alkali syndrome • Vitamin D toxicity •
• Milk-alkali syndrome ... Granulomatous disease • Thiazide
Drugs associated with hypokalemia and hypomagnesemia Hypokalemia - Shift from extracellular fluid to intracellular fluid compartment -
diuretics - Thiazides ... renal Fanconi syndrome ... Furosemide - Thiazide
Outpatient Hypertension Management Algorithm Monotherapy: • Thiazide/thiazide-like • ACE-I (non-black patients), • ARB
Monotherapy: • Thiazide ... /thiazide-like ... Acute Coronary Syndrome
Wernicke's Encephalopathy vs Korsakoff Syndrome - Thiamine Deficiency Wernicke's encephalopathy is a neurological condition due to longstanding
Encephalopathy vs Korsakoff Syndrome ... - Thiamine Deficiency ... to longstanding thiamine ... is Korsakoff's syndrome ... vitaminB1 #B1 #thiamine
Causes of Metabolic Alkalosis: Differential Diagnosis ECF volume contracted: urine chloride concentration <20 meq/L • Gastric alkalosis:
major sweating • Thiazide ... Severe Cushing syndrome ... Congenital AME syndrome ... reabsorptive defect) • Thiazide ... reabsorption at the thiazide-sensitive
Hypomagnesemia - Etiologies by Mechanism Decreased GI Uptake - Poor dietary intake (particularly common in alcoholics)
- Loop and thiazide ... renal Mg wasting syndromes ... - Gitelman syndrome ... - Hungry bones syndrome
Causes of Hypercalcemia Parathyroid hormone–dependent Primary hyperparathyroidism Familial hypocalciuric hypercalcemia Lithium-associated Tertiary hyperparathyroidism Genetic disorders (e.g., multiple endocrine neoplasia type 1 or
Other humoral syndromes ... disease - Williams syndrome ... intoxication, milk-alkali syndrome ... , thiazide diuretics
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 Thiamine Deficiency - Differential Diagnosis Framework and Clinical Manifestations Causes of Thiamine Deficiency: • Poor intake: - Diets
Thiamine Deficiency ... - Refeeding syndrome ... Wernicke-Korsakoff Syndrome ... • Korsakoff Syndrome ... Differential #Diagnosis #syndromes
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