25 results
The Cell Cycle
The cell cycle is the series of tightly regulated steps that controls cell growth
in the case of p53 ... Thats right, p53 ... is too great, p53 ... Yes, its p53 (and ... Retinoblastoma #tp53
Hobnail variant of PTC: micropapillary architecture, dense eosinophilic cytoplasm, hobnail cells with apical nuclei, and marked
Frequent BRAF V600E, TP53
ANCA-Associated Vasculitis
A group of necrotizing, small-vessel vasculitis without immune complex deposition. Complement levels are normal due
associated with PR3 ... involvement - PR3 ... 75-90%, rarely PR3 ... disease - MPO>PR3 ... + almost 100%, PR3
ANA (Antinuclear Antibody) and ANCA (Antineutrophil cytoplasmic antibodies)
 • Systemic lupus erythematosus
   1. Anti-dsDNA
polyangiitis - MPO>PR3 ... polyangiitis - PR3 ... involvement - PR3 ... Churg-Strauss) - MPO>PR3 ... disease - MPO>PR3
Vasculitis and Vasculitides - Differential Diagnosis Framework

When to Consider Vasculitis:
 • Purpura, ischemic skin lesions
 •
proteinase 3 (PR3 ... in >90%, MPO > PR3 ... Granulomas - MPO > PR3 ... 80% (80-90% have PR3 ... proteinase 3 (PR3
Metformin Treatment in Patients With Type 2 Diabetes and Chronic Kidney Disease Stages 3A, 3B, or
Mar; 41(3): 547-553
Rapidly Progressive Glomerulonephritis (RPGN)
RPGN has three primary pathophysiologic causes differentiated by immunofluorescence

Immune Complex Mediated (granular staining):
Negative IF): • PR3
Causes of Hypercalcemia due to increased Vitamin D levels
 • The BIG 3:
granulomatous diseases: PR3
External Ventricular Drains (EVDs) & ICP waveform interpretation
An EVD is a temporary closed sterile system that
compliance) • P3 ... with P1 > P2, P3 ... with P2 > P1, P3
Woltman’s sign on Physical Exam - Hi-Res .mp4 version here: https://www.grepmed.com/images/13248

53-year-old man presented with fatigue and
images/13248 53