14 results
Warm Antibody Autoimmune Hemolytic Anemia 
1) DIAGNOSE AIHA
 • Anemia: macrocytic > normocytic, ↑ reticulocytes
 •
Warm Antibody Autoimmune ... 1) DIAGNOSE AIHA ... C3d • Blood smear ... Pouchelon #Warm #Antibody ... #Anemia #diagnosis
Hemolytic Anemia - Differential Diagnosis Algorithm
Hereditary:
 • Peripheral blood smear + DAT + further History
 •
Hemolytic Anemia ... - Differential Diagnosis ... Peripheral blood smear ... malignancy, autoimmune disease ... #Differential #Diagnosis
Pancytopenia - Differential Diagnosis

Congenital Diseases:
• GATA2 deficiency
• Fanconi’s anemia
• Wiskott-Aldrich syndrome
• Ribosomopathy or telomeropathy

Cancer:
• Leukemia
• Lymphoma

Inflammatory
- Differential Diagnosis ... Congenital Diseases ... and Autoimmune Diseases ... hemoglobinuria • Antibody-mediated ... hemolysis Nutritional
Hemolysis - Differential Diagnosis Framework

1) Environment
  - Fragmentation
  - MAHA: TTP, HUS, DIC, HELLP
Hemolysis - Differential ... Diagnosis Framework ... , Drugs, Liver Disease ... Peripheral Blood Smear ... #Differential #Diagnosis
Cold Agglutinin Disease

3 Types of Cold Sensitive Antibodies:
  1. Cold Agglutinins (CAD)
  2. Donath-Landsteiner
Diagnosis: • hemolytic ... • Compensated hemolysis ... IgM) • Blood smear ... Differential Diagnosis ... #hemolytic #anemia
Plasmodium vivax on peripheral smear
A college student presents w/ headache, fever, chills. Returned 2 days ago
on peripheral smear ... Diagnosis? ... Diagnostic morphologic ... size amoeboid trophozoite ... University Infectious Diseases
TTP - Laboratory Evaluation for Thrombotic Thrombocytopenic Purpura

Activity of von Willebrand factor-cleaving protease activity - A
activity is the diagnostic ... hallmark for the disease ... available for rapid diagnosis ... Peripheral blood smear ... ThromboticThrombocytopenicPurpura #Diagnosis
Hypersensitivity Types and Their Mechanisms
Type I - lgE - Soluble antigen
 - Allergen-specific lgE antibodies bind
- IgG or IgM antibody ... types or during hemolytic ... disease of the ... antigen - Antigen-antibody ... Pathophysiology #Allergy #Diagnosis
Oroya Fever
Hematologic disease caused by Bartonella bacilliformis
Restricted to the Andes highlands of Peru & Ecuador
B. bacilliformis:
Fever Hematologic disease ... lysis → severe hemolytic ... Nodular → Mular DIAGNOSIS ... phase: Peripheral smear ... #Oroya #Fever #diagnosis
Approach to Thrombocytosis - Elevated Platelet Count - Differential Diagnosis Algorithm

Peripheral Smear concerning for malignancy?
- Differential Diagnosis ... Peripheral Smear ... blood loss, Acute hemolysis ... Vasculitides, IBD, Celiac disease ... #Differential #Diagnosis