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diagnosis hematology anemia algorithm autoimmune antibody causes cold disease extravascular intravascular management platelets rheumatology table testing thrombocytosis thromboticthrombocytopenicpurpura treatment ttp
Hemolytic Anemias - Differential Diagnosis Algorithm Signs of anemia and hemolysis: • ↓ Haptoglobin • ↑ LDH
Hemolytic Anemias ... and hemolysis: ... Abnormal peripheral smear ... Anemias (AIHAs) ... #Anemias #Differential
Autoimmune Hemolytic Anemia (AIHA) - Differential Diagnosis Table Warm AIHA (48-70%) Cold AHA (16-32%) • Donath-Landsteiner HA (paroxysmal
Autoimmune Hemolytic ... Anemia (AIHA) - ... hemoglobinuria) • Cold Agglutinin ... #Autoimmune #Hemolytic ... #Anemia #AIHA #
Warm Antibody Autoimmune Hemolytic Anemia 1) DIAGNOSE AIHA • Anemia: macrocytic > normocytic, ↑ reticulocytes •
Antibody Autoimmune Hemolytic ... AIHA • Anemia ... reticulocytes • Hemolysis ... : Differential → ... Antibody #Autoimmune #Hemolytic
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
Framework for Hemolysis ... Intravascular Hemolysis ... Microangiopathic hemolytic ... purpura (TTP), Hemolytic ... . primary cold agglutin
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
women • 15% of AIHA ... Diagnosis: • hemolytic ... • Compensated hemolysis ... intravascular hemolysis ... #disease #hemolytic
Hemolytic Anemia - Differential Diagnosis Algorithm • Sickle cells - Consider sickle cell disease (diverse genotypes):
Hemolytic Anemia ... elliptocytosis, autoimmune hemolysis ... ARUPConsult @ARUPLabs #Hemolytic ... #Anemia #Differential ... Diagnosis #Algorithm #workup
Hemolysis - Differential Diagnosis Framework 1) Environment - Fragmentation - MAHA: TTP, HUS, DIC, HELLP
Hemolysis - Differential ... Autoimmune: Warm AIHA ... Defects: Sickle cell anemia ... Peripheral Blood Smear ... Urobilinogen #Hemolysis
TTP - Laboratory Evaluation for Thrombotic Thrombocytopenic Purpura Activity of von Willebrand factor-cleaving protease activity - A
hemorrhage and hemolysis ... intravascular hemolysis ... Peripheral blood smear ... out an immune hemolytic ... the severity of hemolysis
Approach to Thrombocytosis - Elevated Platelet Count - Differential Diagnosis Algorithm Peripheral Smear concerning for malignancy?
Platelet Count - Differential ... Peripheral Smear ... hematology for workup ... blood loss, Acute hemolysis ... , deficiency anemia
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