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diagnosis hematology anemia algorithm extravascular hemolysis antibody autoimmune classification cold deficiency disease fe iron management thromboticthrombocytopenicpurpura treatment ttp warm workup
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
Causes Intravascular ... . primary cold agglutin ... #Hemolytic #Intravascular ... #Causes #differential ... #diagnosis #hematology
Causes of Extravascular and Intravascular Hemolysis - Differential Diagnosis Algorithm Extravascular - Spleen and RES-mediated hemolysis -
Causes of Extravascular ... Hemolysis - Differential ... Differential #Diagnosis ... #Algorithm #Causes ... #Hematology
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
IgM) • Blood smear ... younger pts) Differential ... the RBCs causing intravascular ... #disease #hemolytic ... #anemia #hematology
Warm Antibody Autoimmune Hemolytic Anemia 1) DIAGNOSE AIHA • Anemia: macrocytic > normocytic, ↑ reticulocytes •
Antibody Autoimmune Hemolytic ... C3d • Blood smear ... : Differential → ... 2) LOOK FOR a cause ... management #treatment #rheumatology
Differential Diagnosis for Hemolytic Anemia Intrinsic Causes: • Enzyme deficiencies ex. G6PD, pyruvate kinase • Hemoglobinopathies
Differential Diagnosis ... for Hemolytic Anemia ... IVIG infusion Intravascular ... #Anemia #Differential ... classification #hematology
TTP - Laboratory Evaluation for Thrombotic Thrombocytopenic Purpura Activity of von Willebrand factor-cleaving protease activity - A
decrease in most cases ... reflection of intravascular ... Peripheral blood smear ... WBC count and differential ... Diagnosis #Workup #Hematology
Causes of Iron Deficiency - Differential Diagnosis Algorithm • Blood loss: GI (cancer, ulcer, IBD), GU
Causes of Iron Deficiency ... - Differential ... • Iron loss: Intravascular ... hemolysis, (PNH ... hepcidin: Chronic kidney
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