19 results
Hemolytic Anemias - Differential Diagnosis Algorithm

Signs of anemia and hemolysis:
 • ↓ Haptoglobin
 • ↑ LDH
Hemolytic Anemias ... Reticulocytes • Abnormal peripheral ... smear Immune-mediated ... Anemias (AIHAs) ... Anemias (AHAs)
Laboratory Testing in Hemolytic Anemia

Intravascular vs Extravascular Hemolysis
Reticulocytes
Unconjugated bilirubin
LDH
Peripheral smear
Haptoglobin
Urine hemosiderin
Urine hemoglobin
Carboxyhemoglobin

#Hemolytic #Anemia #Laboratory #Testing #workup
Anemia Intravascular ... Extravascular Hemolysis ... bilirubin LDH Peripheral ... smear Haptoglobin ... #Anemia #Laboratory
Plasmodium Falciparum Blood Smear.
Key features suggesting Plasmodium falciparum:
- extreme parasitemia
- normocytic RBCs (vivax, ovale prefer big
Falciparum Blood Smear ... reticulocytes) - thin trophozoites ... ~75% of human malaria ... #peripheral #clinical ... #microbiology #malaria
Hemolytic Anemia - Differential Diagnosis Algorithm
Hereditary:
 • Peripheral blood smear + DAT + further History
 •
Hemolytic Anemia ... Hereditary: • Peripheral ... blood smear + DAT ... → Sickle Cell anemia ... Malaria, Clostridium
Peripheral Blood Smear Analysis
Hypochromia
Megaloblastic Anemia
Schistocytes: Microangiopathic hemolytic anemia (e.g. DIC, TTP, HUS)
Microspherocytes: Autoimmune hemolytic anemia
Sickled red
Peripheral Blood ... Smear Analysis ... Microangiopathic hemolytic ... Microspherocytes: Autoimmune hemolytic ... #Blood #Smear #
Peripheral blood findings in microangiopathic hemolytic anemia.  DIC is a clinical and laboratory diagnosis, not
Peripheral blood ... anemia. ... (black arrow) Peripheral ... smear changes are ... #Pathology #Smear
Plasmodium falciparum trophozoites (and crenated red blood cells) - Blood Smear

A classic presentation of Plasmodium falciparum
cells) - Blood Smear ... Plasmodium falciparum malaria ... in a thin blood smear ... #peripheral #clinical ... #microscopy #malaria
Spur-Cell Anemia- A 31-year-old man with a history of cirrhosis, recurrent hepatic encephalopathy, and anemia presented
confusion...A peripheral-blood ... smear showed numerous ... , a form of hemolytic ... #peripheral #blood ... #smear
Hemolysis - Differential Diagnosis Framework

1) Environment
  - Fragmentation
  - MAHA: TTP, HUS, DIC, HELLP
Hemolysis - Differential ... Infections/toxins: Malaria ... Defects: Sickle cell anemia ... Dehydrogenase ↑ - Peripheral ... Blood Smear ↑ abnormal
Plasmodium vivax on peripheral smear
A college student presents w/ headache, fever, chills. Returned 2 days ago
Plasmodium vivax on peripheral ... smear A college ... size amoeboid trophozoite ... PlasmodiumVivax #pvivax #malaria ... #peripheral #smear