11 results
diagnosis hematology cirrhosis differential management workup aflp alkphos amyloid amyloidosis arterial astalt biliary bilirubin chemistry cholangitis coagulation dic disorders disseminated
Liver Chemistry Tests - AST, ALT, Alkaline Phosphatase and Bilirubin Metabolism AST and ALT: • AST: liver
, Alkaline Phosphatase ... Alkaline phosphatase ... bile canaliculi (ATP-dependent ... AlkPhos #Bilirubin #Hepatology ... #Pathophysiology
Low Alkaline Phosphatase - Hypophosphatasia Is Low Alkaline Phosphatase Of Clinical Importance? ALP enzyme- Discovered in 1923 Low
synthesized in: liver ... deficiency • blood ... collection with EDTA Pathophysiology ... Phosphatase: • Other causes ... Hyophosphatasia #hepatology
Acute Fatty Liver of Pregnancy (AFLP) Pathophysiology: • Defect in fetal free fatty acid metabolism products →
) Pathophysiology ... = nonspecific (nausea ... , vomiting, abdominal ... Pregnancy #hepatology ... diagnosis #management #pathophysiology
Causes of Thrombocytopenia and Platelet Disorders - Differential Diagnosis and Workup History: - Prior platelet count, family
plateletcount), peripheral blood ... : INR/PT, aPTT(liver ... not required in all ... Refractory ITP, ... #Workup #hematology
Primary Biliary Cirrhosis (PBC) - Summary PBC Epidemiology: • Female:Male 9:1 • Common European descent • Age:
65 years PBC Pathophysiology ... intralobular bile ducts causes ... PBC Labs: • Alkaline ... obstruction • ALP ... diagnosis #workup #hepatology
Disseminated Intravascular Coagulation (DIC) Overview Increased Clotting and Consumption of Clotting Factors Findings: • Bleeding • Recent history
ABO incompatible blood ... protein C and S Pathophysiology ... • TMA’s (HUS/TTP ... DIC • Severe Liver ... Treat primary cause
Major Clinical Trials and Evidence Summary for Transfusion Thresholds in Critical Care TRICC - NEJM 1999 -
NEJM 1999 - ICU FOCUS ... Transfusing blood ... Blood saves lives ... unnecessary and cause ... ALI is the deadliest
Venous Thrombosis vs Arterial Thrombosis - Differential Diagnosis Framework VENOUS THROMBOSIS • Acquired Risk Factors: - >48 hours
Hyperviscosity, TTP ... Syndrome, Ischemic Liver ... considered in all ... coagulation and other causes ... Venous #Arterial #pathophysiology
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
the peripheral blood ... -> AML: Blast crises ... , weight loss, abdominal ... Cytopenias • AIHA, ITP ... #Leukemia #Hematology
Amyloidosis - Summary Group of disorders associated with extracellular deposition of fibrils formed from low-molecular-weight proteins in
→ Mutant TTR → ... hypoadrenalism • Nausea ... Diagnostic Testing Blood ... Creatinine, albumin, alkaline ... Diagnostic imaging of liver
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