11 results
Causes of Thrombocytopenia - Differential Diagnosis Algorithm
 
Decreased Megakaryopoiesis
 • Aplastic Anemia
 • Toxic Damage (e.g.
Causes of Thrombocytopenia ... - Differential ... Megakaryopoiesis • Aplastic Anemia ... Non-lmmune: • HELLP ... #Hematology
Differential Diagnosis for Hemolytic Anemia
Intrinsic Causes:
 • Enzyme deficiencies ex. G6PD, pyruvate kinase 
 • Hemoglobinopathies
Differential Diagnosis ... for Hemolytic Anemia ... : • Liver disease ... : • MAHA: TTP, ... HUS, DIC, HELLP
Hemolysis - Differential Diagnosis Framework

1) Environment
  - Fragmentation
  - MAHA: TTP, HUS, DIC, HELLP
Hemolysis - Differential ... Fragmentation - MAHA: TTP ... , HUS, DIC, HELLP ... Defects, Drugs, Liver ... Defects: Sickle cell anemia
Acute Fatty Liver of Pregnancy (AFLP)
Pathophysiology:
 • Defect in fetal free fatty acid metabolism products →
= nonspecific (nausea ... , vomiting, abdominal ... infiltration) Differential ... Preeclampsia, HELLP ... #Pregnancy #hepatology
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes
Intravascular Hemolysis:
 • Mechanical Trauma (Microangiopathic hemolytic anemia):
Extravascular Causes ... coagulation (DIC) - HELLP ... thrombocytopenic purpura (TTP ... #differential # ... #anemia
PLATELETS Mnemonic for Causes of Thrombocytopenia

P - Platelet Disorders (DIC, ITP, TTP)
L - Leukemia, Lymphoma
A -
PLATELETS Mnemonic for Causes ... , TTP) L - Leukemia ... A - Aplastic Anemia ... Enlarged Spleen L - Liver ... Thrombocytopenia #Differential
Purpura - Differential Diagnosis Framework

Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
Purpura - Differential ... disease - DIC/TTP ... - Hemolytic anemia ... deficiency • Liver ... #Diagnosis #hematology
Causes of Thrombocytopenia and Platelet Disorders - Differential Diagnosis and Workup
History:
 - Prior platelet count, family
Platelet Disorders - Differential ... : INR/PT, aPTT(liver ... changes), high MCV anemia ... Refractory ITP, ... #Workup #hematology
Venous Thrombosis vs Arterial Thrombosis - Differential Diagnosis Framework

VENOUS THROMBOSIS

 • Acquired Risk Factors:
	- >48 hours
Hyperviscosity, TTP ... Syndrome, Ischemic Liver ... coagulation and other causes ... Venous #Arterial #pathophysiology ... #hematology #differential
Portal venous gas on hepatic ultrasound: A concerning finding in the critically ill patient that should
reflection on the differential ... ileus), intra-abdominal ... variety of other causes ... venousgas #ultrasound #hepatology ... #liver #pocus #