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diagnosis causes algorithm abnormal anemia aptt oncology prolonged pt apml bleeding bruising calculation differentiation extravascular focal hemolysis hemolytic increased index
Causes of Bleeding / Bruising - Differential Diagnosis Algorithm Thrombocytopenia - Quantitative Defect • Decreased Production •
Bleeding / Bruising - Differential ... Rare • Drugs (e.g ... • Vasculitis Coagulation ... Bleeding #Bruising #Differential ... Algorithm #Causes #Hematology
Liver Mass - Differential Diagnosis Algorithm Benign Cystic • Cyst • Polycystic Liver Disease • Caroli's
Liver Mass - Differential ... • Metastases (e.g ... Lung, Colon, Breast ... #Liver #Mass #Hepatology ... #Differential #
Causes of Localized Lymphadenopathy - Differential Diagnosis Algorithm Cervical: - Anterior • Infection
Lymphadenopathy - Differential ... • Infection (e.g ... Thoracic Malignancy (Breast ... Thoracic Wall, Breast ... Algorithm #Causes #Hematology
Causes of Neutrophilia - Increased Neutrophils - Differential Diagnosis Algorithm Infection • Bacterial • Abscess • Viral Medications
Neutrophils - Differential ... Solid Tumour (e.g ... (pancytopenia, blast ... #Neutrophils #Differential ... Algorithm #Causes #Hematology
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
intravascular coagulation ... (usually IgG) (e.g ... (usually IgM) (e.g ... Extravascular #Causes #differential ... #diagnosis #hematology
Reticulocyte Production Index = (Retic %) x (Hct / 45) / Maturation Factor The maturation factor is
infiltration (e.g ... Marrow suppression (e.g ... Production #Index #hematology ... #anemia #differential ... #diagnosis #calculation
Causes of Abnormal PT and/or aPTT Prolonged Prothrombin Time (PT) 1. Acquired deficiency of FVII
Congenital intrinsic coagulation ... to one factor e.g ... intravascular coagulation ... Causes #diagnosis #differential ... #hematology #coagulation
Differential Diagnosis for a Prolonged PT and aPTT If the PT and the aPTT are both prolonged,
Differential Diagnosis ... inhibitory drugs (e.g ... specific inhibitor (e.g ... Causes #diagnosis #differential ... #hematology #coagulation
Differentiation Syndrome in APML Epidemiology: • Incidence: common in APL (2-48% depending on the study) • Triggers:
Cytokine Release from blast ... damage • Induce blast ... Prednisone 5mg/kg ... initiation • Differential ... diagnosis #management #hematology
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