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diagnosis nephrology causes algorithm potassium alkalosis hypokalemia hyperkalemia low metabolic framework hypophosphatemia management rheumatology weakness workup acidbase acidosis behcet comatose
Pathophysiology of Tumor Lysis Syndrome (TLS) Tumor Cell Lysis -> Release of DNA • Purines -> Hypoxanthine /
Pathophysiology ... of Tumor Lysis Syndrome ... (TLS) Tumor Cell ... -> Allantoin (High ... #TLS #Pathophysiology
Leukostasis vs Tumor Lysis Syndrome Leukostasis: • Pathophysiology: Large, immature blasts and high WBC count cause hyperviscosity
Leukostasis vs Tumor ... /- rasburicase Tumor ... : Lysis of tumor ... rate or large tumor ... #Leukostasis #Tumor
Primary Metabolic Alkalosis - Differential Diagnosis Algorithm Volume Depleted 2° hyperaldosteronism • Low Urine Cl-: Vomiting, NGT
Metabolic Alkalosis - Differential ... Diuretics (late) • High ... hyperaldosteronism • High ... Renin-secreting tumor ... Diagnosis #Algorithm #nephrology
Hypokalemia - Differential Diagnosis Algorithm Extra-renal Losses: • Normal Acid-Base: Low intake • Metabolic acidosis: Gl tract
Hypokalemia - Differential ... • HTN, High Aldosterone ... Renin secreting tumor ... #Hypokalemia #Differential ... potassium #low #nephrology
Primary Metabolic Alkalosis - Differential Diagnosis Algorithm Volume Depleted - 2° hyperaldosteronism • Low Urine Cl-: Vomiting,
Metabolic Alkalosis - Differential ... Diuretics (late) • High ... hyperaldosteronism • High ... Renin-secreting tumor ... Diagnosis #Algorithm #Nephrology
Hypokalemia Differential Diagnosis Algorithm Hypertensive: • High Al, Low R - Primary aldosteronism • High Al, High
Hypokalemia Differential ... Hypertensive: • High ... Renin-secreting tumor ... #Hypokalemia #Differential ... Diagnosis #Algorithm #nephrology
Causes of Neuromuscular Weakness • Spinal Cord: Demyelinating Disease (MS), Epidural abscess, Infarction, Syringomyelia, Tetanus, Transverse
Myelitis, Trauma, Tumor ... Motor Nerves: ALS ... Guillain-Barre syndrome ... Weakness #Causes #differential ... #diagnosis #neurology
Causes of HyperKalemia - Differential Diagnosis Increased extracellular K+: • Tissue injury • Hemolysis • Rhabdomyolysis •
HyperKalemia - Differential ... Rhabdomyolysis • Tumor ... lysis syndrome ... glycosides • High ... blockers - MCW Nephrology
Causes of Metabolic Alkalosis - Differential Diagnosis Algorithm GI Losses - Gastric • Vomiting • NG suction GI
Metabolic Alkalosis - Differential ... Renin-Secreting Tumor ... Licorice • Liddle's Syndrome ... MetabolicAlkalosis #NonGap #Nephrology ... #Differential #
Workup for Hypophosphatemia - Differential Diagnosis Framework Rule out spurious hypophosphatemia: paraproteinemia, acute leukemia Measure Urine Fractional Excretion
Hypophosphatemia - Differential ... , Tumor genesis ... • Normal or High ... Low PTH: - High ... Workup #phosphate #nephrology
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