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Rapidly Progressive Glomerulonephritis (RPGN)
RPGN has three primary pathophysiologic causes differentiated by immunofluorescence

Immune Complex Mediated (granular staining):
three primary pathophysiologic ... Idiopathic • Normal ... Complement: IgA ... Glomerulonephritis #Vasculitis #differential ... #diagnosis #algorithm
C5-C9 Deficiency - Pathogenesis and Clinical Findings
Note:
 • Risk of invasive meningococcal disease is 1000-10000x higher
fatality is rare Normal ... complement response ... : The complement ... activation -> Complement ... #pathophysiology
Hypersensitivity Types and Their Mechanisms
Type I - lgE - Soluble antigen
 - Allergen-specific lgE antibodies bind
antigen, leading to complement ... Complement activation ... Hypersensitivity #Types #Classification ... #Pathophysiology
Hemolytic Anemias - Differential Diagnosis Algorithm

Signs of anemia and hemolysis:
 • ↓ Haptoglobin
 • ↑ LDH
Hemolytic Anemias - Differential ... Diagnosis Algorithm ... Reticulocytes • Abnormal ... Hemolytic #Anemias #Differential ... #Diagnosis #Algorithm
Lymphomas and Lymphoproliferative Disorders - Differential Diagnosis Algorithm
Hodgkin Lymphoma ~40% - Characteristic For Reed-Sternberg (RS) Cells
Lymphoproliferative Disorders - Differential ... Diagnosis Algorithm ... Lymphoproliferative #Disorders #Classification ... #pathophysiology ... #algorithm
Blood Disorders - Markers and Differential Diagnosis Algorithm 
Acute
 • Myloid (AML) - CD13, CD33, CD34,
- Markers and Differential ... Diagnosis Algorithm ... Myelodysplastic Disorder - Abnormal ... hematology #Markers #Differential ... #Diagnosis #Algorithm
Abnormal Lipid Profiles - Differential Diagnosis Algorithm

Increased Cholesterol and Triglycerides 
 - Genetic Causes
Abnormal Lipid Profiles ... - Differential ... Diagnosis Algorithm ... #Dyslipidemia #Abnormal ... #Diagnosis #Algorithm
Abnormal liver function tests algorithm.
 This figure details the initial response to abnormal liver blood tests.
Abnormal liver function ... tests algorithm ... initial response to abnormal ... #Algorithm #Hepatology ... Liver #Enzymes #Differential