Dr. Gerald Diaz @GeraldMD
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Board Certified Internal Medicine Hospitalist, GrepMed Editor in Chief πŸ‡΅πŸ‡­ πŸ‡ΊπŸ‡Έ - Sign up for an account to like, bookmark and upload images to contribute to our community platform. Follow us on IG: https://www.instagram.com/grepmed/ | Twitter: https://twitter.com/grepmeded/
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Thrombocytopenia and Pregnancy - TTP/HUS, HELLP Syndrome and Acute Fatty Liver of Pregnancy (AFLP)
Three syndromes in
) Three syndromes ... child * Severe cases ... #obstetrics #hematology ... #diagnosis #table ... #comparison
Thrombocytopenia and Pregnancy
Three syndromes in the critically ill pregnant woman who presents with coagulation defects.
1) HELLP
Pregnancy Three syndromes ... child * Severe cases ... TTPHUS #HELLP #AFLP ... Obstetrics #OBGyn #Hematology ... #Diagnosis #Comparison
Liver Disease in Pregnancy
Intrahepatic Cholestasis of Pregnancy (ICP)
 β€’ Onset/Trimester: 25-32 weeks
 β€’ Typical clinical features:
necrosis HELLP Syndrome ... of Pregnancy (AFLP ... obstetrics #hepatitis #comparison ... #differential #diagnosis ... #icp #HELLP #AFLP
Diagnostic Framework for Anemia (Morphological Approach - MCV)
Low MCV - <80fL - "Microcytic"
 β€’ Iron deficiency
Diagnostic Framework ... disease, Acute blood ... : Alcohol use, Liver ... Myelodysplastic syndrome ... #causes #hematology
Summary of Coagulation Deficiencies
Inherited:
 β€’ Hemophilia A - Deficiency of Factor VIII
 β€’ Hemophilia B -
Malabsorption (e.g ... warfarin, DOACs (e.g ... ) β€’ Advanced Liver ... Summary #table #comparison ... #diagnosis #hematology
Red Blood Cell (RBC) Morphology Atlas
 β€’ Microcytic - Iron-deficiency anemia, Thalassemia, Sideroblastic anemia, Lead poisoning
Red Blood Cell ( ... Myelodysplastic syndrome ... Hemolytic uremic syndrome ... Morphology #Atlas #key #diagnosis ... #differential #hematology
Causes of Thrombocytosis - Differential Diagnosis
Secondary Thrombocytosis (a.k.a Reactive Thrombocytosis):
 β€’ Acute infection
 β€’ Solid organ
Causes of Thrombocytosis ... - Differential Diagnosis ... inflammatory disorders (e.g ... Myelodysplastic syndrome ... #Causes #hematology
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes
Intravascular Hemolysis:
 β€’ Mechanical Trauma (Microangiopathic hemolytic anemia):
Diagnostic Framework ... Extravascular Causes ... ) - HELLP syndrome ... Hemolytic uremic syndrome ... #hematology #anemia
Differential Diagnosis for a Prolonged PT and aPTT
If the PT and the aPTT are both prolonged,
Differential Diagnosis ... Causes include : ... β€’ Reduced liver ... #diagnosis #differential ... #hematology #coagulation
Red Blood Cell (RBC) Morphology
Microcytic RBC: Pyridoxine deficiency, Thalassemia, Iron deficiency anemia, Chronic disease anemia (sometimes),
Red Blood Cell ( ... Chemotherapy (e.g ... disease, McLeod blood ... #differential #diagnosis ... #hematology #microscopy