Dr. Gerald Diaz @GeraldMD
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Board Certified Internal Medicine Hospitalist, GrepMed Editor in Chief πŸ‡΅πŸ‡­ πŸ‡ΊπŸ‡Έ - Sign up for an account to like, bookmark and upload images to contribute to our community platform. Follow us on IG: https://www.instagram.com/grepmed/ | Twitter: https://twitter.com/grepmeded/
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Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes
Intravascular Hemolysis:
 β€’ Mechanical Trauma (Microangiopathic hemolytic anemia):
Diagnostic Framework ... Microangiopathic hemolytic anemia ... ) - HELLP syndrome ... Hemolytic uremic syndrome ... #hematology #anemia
Red Blood Cell (RBC) Morphology
Microcytic RBC: Pyridoxine deficiency, Thalassemia, Iron deficiency anemia, Chronic disease anemia (sometimes),
Iron deficiency anemia ... anemia (sometimes ... Chemotherapy (e.g ... #differential #diagnosis ... #hematology #microscopy
Red Blood Cell (RBC) Morphology Atlas
 β€’ Microcytic - Iron-deficiency anemia, Thalassemia, Sideroblastic anemia, Lead poisoning
, Liver diseases ... Myelodysplastic syndrome ... Hemolytic uremic syndrome ... Morphology #Atlas #key #diagnosis ... #differential #hematology
Diagnostic Framework for Anemia (Morphological Approach - MCV)
Low MCV - <80fL - "Microcytic"
 β€’ Iron deficiency
Diagnostic Framework ... chronic kidney disease ... Myelodysplastic syndrome ... #differential #diagnosis ... #causes #hematology
Autoantibodies and their Disease Associations
ANA - Non-specific; common in SLE, autoimmune hepatitis
Anti-CCP, Rheumatoid factor - RA
Anti-dsDNA
La) - Sjogren's syndrome ... - Vasculitis, e.g ... - Vasculitis, e.g ... #diagnosis #table ... #rheumatology #
Reticulocyte Production Index = (Retic %) x (Hct / 45) / Maturation Factor
The maturation factor is
Chronic kidney disease ... infiltration (e.g ... Marrow suppression (e.g ... Production #Index #hematology ... #diagnosis #calculation
Connective tissue disease-associated interstitial lung diseases

LIP: lymphoid interstitial pneumonia. NSIP: nonspecific interstitial pneumonia. OP: organizing pneumonia.
interstitial lung diseases ... PSS: Sjogren syndrome ... LungDisease #CTILD #Diagnosis ... #Differential #Comparison ... Table #Pulmonary #Rheumatology
Causes of Thrombocytosis - Differential Diagnosis
Secondary Thrombocytosis (a.k.a Reactive Thrombocytosis):
 β€’ Acute infection
 β€’ Solid organ
- Differential Diagnosis ... malignancies β€’ Anemia ... inflammatory disorders (e.g ... Myelodysplastic syndrome ... #Causes #hematology
Causes of Pleural Effusion - Differential Diagnosis Algorithm
Transudate - Hydrostatic
 β€’ Congestive heart failure
 β€’ Constrictive
- Differential Diagnosis ... Collagen vascular disease ... Gastrointestinal disease ... β€’ Asbestos β€’ Uremia ... #Algorithm #Hepatology
Summary of Coagulation Deficiencies
Inherited:
 β€’ Hemophilia A - Deficiency of Factor VIII
 β€’ Hemophilia B -
Malabsorption (e.g ... . celiac disease ... Advanced Liver Disease ... Summary #table #comparison ... #diagnosis #hematology