Dr. Gerald Diaz @GeraldMD
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Board Certified Internal Medicine Hospitalist, GrepMed Editor in Chief πŸ‡΅πŸ‡­ πŸ‡ΊπŸ‡Έ - Sign up for an account to like, bookmark and upload images to contribute to our community platform. Follow us on IG: https://www.instagram.com/grepmed/ | Twitter: https://twitter.com/grepmeded/
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Von Willebrand Disease - Clinical Presentation, Diagnosis and Management

- Dr. Eric Strong @DrEricStrong - Strong Medicine
Von Willebrand Disease ... - Clinical Presentation ... , Diagnosis and ... VonWillebrand #Disease ... #hematology #treatment
Causes of Hypocomplementemia - CHAMPS Mnemonic
C - Cryoglobulinemia (85%), C3 glomerulopathy, cirrhosis
H - Heavy Chain deposition
Causes of Hypocomplementemia ... Chain deposition disease ... antiphospholipid syndrome ... #differential # ... hematology
Acquired von Willebrand Syndrome - Diagnosis and Management
 β€’ Autoantibodies to vWF: Lymphoproliferative disorders (e.g. lymphoma,
von Willebrand Syndrome ... - Diagnosis and ... thrombocythemia), Autoimmune disease ... #treatment #hematology ... #differential
Causes of Thrombocytosis - Differential Diagnosis
Secondary Thrombocytosis (a.k.a Reactive Thrombocytosis):
 β€’ Acute infection
 β€’ Solid organ
- Differential ... Diagnosis Secondary ... Myelodysplastic syndrome ... #Diagnosis #Causes ... #hematology #secondary
Myelodysplastic Syndrome (MD) - Diagnosis and Management Summary
myelo (marrow) -dys- (abnormal) -plastic (shape) = funny-shaped cells
Myelodysplastic Syndrome ... old, ~10,000 new cases ... only curative treatment ... #Management #treatment ... #hematology #oncology
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes
Intravascular Hemolysis:
 β€’ Mechanical Trauma (Microangiopathic hemolytic anemia):
Diagnostic Framework ... Extravascular Causes ... ) - HELLP syndrome ... #differential # ... diagnosis #hematology
Differential Diagnosis for Hemolytic Anemia
Intrinsic Causes:
 β€’ Enzyme deficiencies ex. G6PD, pyruvate kinase 
 β€’ Hemoglobinopathies
Differential Diagnosis ... : β€’ Liver disease ... Hemolytic #Anemia #Differential ... #Diagnosis #causes ... classification #hematology
Diagnostic Framework for Anemia (Morphological Approach - MCV)
Low MCV - <80fL - "Microcytic"
 β€’ Iron deficiency
Diagnostic Framework ... Myelodysplastic syndrome ... morphologic #mcv #differential ... #diagnosis #causes ... #hematology
Von Willebrand Disease - Most common inherited bleeding disorder 
Clinical 
 β€’ Easy bruising 
 β€’
Von Willebrand Disease ... bleeding disorder Clinical ... factor VIII) Treatment ... VonWillebrand #Disease ... #Diagnosis #Hematology
Pancytopenia - Workup and Differential Diagnosis Algorithm
Consumption Disorders
 1. Autoimmune Mediated Pancytopenia
 2. Splenic Sequestration
Peripheral Destruction
Diagnosis Algorithm ... HLH syndrome 5. ... marrow failure syndrome ... Metastatic Disease ... #Hematology