Dr. Gerald Diaz @GeraldMD
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Board Certified Internal Medicine Hospitalist, GrepMed Editor in Chief πŸ‡΅πŸ‡­ πŸ‡ΊπŸ‡Έ - Sign up for an account to like, bookmark and upload images to contribute to our community platform. Follow us on IG: https://www.instagram.com/grepmed/ | Twitter: https://twitter.com/grepmeded/
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Alkalinization shifts equilibrium toward the plasma and urine and away from the tissues.

#Management #Toxicology #Salicylate #Aspirin
#Management #Toxicology ... #Salicylate #Aspirin ... #Toxicity #Alkalinization
Acetaminophen metabolism and factors affecting toxicity. 
GSH = glutathione 

#Acetaminophen #APAP #metabolism #toxicity #Toxicology #Pathophysiology #Overdose
Acetaminophen metabolism ... factors affecting toxicity ... glutathione #Acetaminophen ... APAP #metabolism #toxicity ... #Toxicology #Pathophysiology
High Anion Gap Metabolic Acidosis (HAGMA) - Differential Diagnosis - GOLDMARK

Glycols - ethylene and propylene glycol
Oxoproline
associated with acetaminophen ... Aspirin - salicylate ... toxicity causes
Intravenous Lipid Emulsion (ILE) Therapy

ILE is a treatment for severe toxicity from local anesthetics. In addition,
treatment for severe toxicity ... life-threatening toxicity ... #ILE #Therapy #Toxicology ... #Management #Pharmacology
Salicylate Effect on Oxidative Phosphorylation (www.derangedphysiology.com)
#Pathophysiology #Toxicology #Toxicity #Salicylate #Aspirin #Oxidative #Phosphorylation
Pathophysiology #Toxicology ... #Toxicity #Salicylate ... #Aspirin #Oxidative
Salicylate Toxicity - Diagnosis and Management

Consider if:
1) Patient is hot and altered
2) You see tachypnea with
Salicylate Toxicity ... #Salicylate #Aspirin ... #Toxicity #Toxicology
Salicylate Toxicity - Diagnosis and Management

Clinical Findings
Pathophysiology
Workup
Treatment

By Stacy Marshall, MD

#Salicylate #Toxicity #Diagnosis #Management #Toxicology #Aspirin #Treatment
Salicylate Toxicity ... #Salicylate #Toxicity ... Diagnosis #Management #Toxicology ... #Aspirin #Treatment
Utilization of Antibiotics as Antidotes

Valproic Acid Toxicity:
Carbapenems 

Amatoxin Mushrooms: 
Polymyxin B, Penicillin, Cyclosporine

Infographic by Mike O'Brien
@MikeEMPharmD

#Antibiotics
Valproic Acid Toxicity ... Antibiotics #Antidotes #Toxicology ... #Pharmacology
Gamma hydroxybutyrate (GHB) - Toxicology

Clinical presentation
 - Symptoms of GHB toxicity include: short term anterograde amnesia,
hydroxybutyrate (GHB) - Toxicology ... Symptoms of GHB toxicity ... Hydroxybutyrate #GHB #Toxicology ... #Toxicity #Diagnosis ... #Management #Pharmacology
Carbamazepine Toxicity

Carbamazepine (CBZ) is an antiepileptic drug commonly prescribed for seizure disorders, trigeminal neuralgia, neuropathic pain,
Carbamazepine Toxicity ... Carbamazepine #Toxicity ... #Toxicology #Diagnosis ... SideEffects #Adverse #Pharmacology