Dr. Gerald Diaz @GeraldMD
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Board Certified Internal Medicine Hospitalist, GrepMed Editor in Chief 🇵🇭 🇺🇸 - Sign up for an account to like, bookmark and upload images to contribute to our community platform. Follow us on IG: https://www.instagram.com/grepmed/ | Twitter: https://twitter.com/grepmeded/
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management dermatology clinical hemophagocytic lymphohistiocytosis adultonset anemia blood comparison product rash reactions stills summary syndrome vasculitis acute aosd aplastic canimorsus
Hemophagocytic Lymphohistiocytosis (HLH) Definition: Overwhelming clinical syndrome associated with excessive macrophage activation and cytokine storm due to
age, however the disease ... can mimic common infections ... : • Infection ... rapidly, and empiric antibiotic ... #hematology
Hemophagocytic Lymphohistiocytosis (HLH) Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
• Autoimmune diseases ... Adult-onset Still disease ... Unknown cause Treatment ... #management #treatment ... #summary #rheumatology
Hemophagocytic Lymphohistiocytosis (HLH) Treatment Primary HLH: - HLH-94 Protocol • Dexamethasone
) Treatment Primary ... associated with infection ... or autoimmune disease ... for refractory disease ... #hematology
Non-HCV infectious mixed cryoglobulinemia vasculitis - Diagnosis, causes and management - French Vasculitis Study Group < 5%
cryoglobulinemia vasculitis - Diagnosis ... neuropathy Treatment ... with refractory disease ... Cryoglobulinemia #Vasculitis #Rheumatology ... Cryoglobulinemic #Diagnosis
Aplastic Anemia - Illness Script Signs and symptoms: • Recurrent infections from neutropenia • Mucosal bleeding from
: • Recurrent infections ... Symptomatic anemia Diagnosis ... (transfusions, antibiotics ... #management #treatment ... #hematology
Adult-Onset Still's Disease Clinical triad: Fever, Arthralgia/arthritis, Skin rash ± odynophagia + Biological inflammation: Increased neutrophils, Hyperferritinemia, decreased
Adult-Onset Still's Disease ... Differential Diaqnoses ... : • Infectious ... #diagnosis #management ... #treatment #rheumatology
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
Diagnostic Framework ... Drugs (Beta lactam antibiotics ... spherocytosis) • Infections ... #differential #diagnosis ... #hematology #anemia
Summary of Coagulation Deficiencies Inherited: • Hemophilia A - Deficiency of Factor VIII • Hemophilia B -
malnutrition, Antibiotics ... Advanced Liver Disease ... Deficiencies #Summary #table ... #comparison #diagnosis ... #hematology #deficiency
Kawasaki Disease (KD) - Diagnosis and Management Summary Kawasaki Disease (KD) is the most common vasculitis of
Kawasaki Disease ... (KD) - Diagnosis ... cæxist with other infections ... KD #vasculitis #rheumatology ... #management #treatment
Adult-Onset Still's Disease (AOSD) Rare inflammatory disorder of unknown etiology, difficult to diagnose because of heterogenous presentation.
Adult-Onset Still's Disease ... susceptibility, infectious ... synovitis (40%) Treatment ... #AOSD #rheumatology ... #treatment
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