The Calgary Guide to Understanding Disease @TheCalgaryGuide
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pathophysiology signs ophthalmology 21hydroxylasedeficiency bonetumors bony chronic complications diabetes diabeticketoacidosis diffuse endocin excess genetics gh gravesdisease growthhormone hydrocele hypertensive overproduction
Diabetic Ketoacidosis (DKA) - Pathogenesis and Clinical Findings • Note: in DKA, body K+ is lost
Ketoacidosis (DKA ... Findings • Note: in DKA ... Treating DKA: 1) ... Signs/Symptoms/Complications ... pathophysiology #endocrinology
21-Hydroxylase Deficiency (21-OHD): Pathogenesis and Clinical Findings Autosomal recessive mutation in CYP21A2 coding for the enzyme 21-OHase
Signs/Symptoms/Complications ... #21HydroxylaseDeficiency #21OHD ... pathophysiology #genetics #endocrinology
Retinoblastoma: Pathogenesis and clinical findings • Sporadic mutation -> One allele of RB1 tumor suppressor gene
second hit' -> Malignant ... second hit' -> Malignant ... Retinoblastoma Signs / Symptoms ... ophthalmology #diagnosis ... #signs #symptoms
Graves’ Disease: Pathogenesis and Clinical Findings B & T lymphocyte mediated autoimmunity attack TSH receptor -> Continuous
etiology Signs/Symptoms ... pathophysiology #endocin #endocrinology ... #symptoms #signs ... #diagnosis
Malignant Bone Tumors: Pathogenesis of X-ray appearance • Metastatic bone tumors (aka. cancerous cells from systemic
Malignant Bone Tumors ... Metastatic bone tumors (aka ... Signs/Symptoms: ... #BoneTumors #Malignant ... #Radiology #Diagnosis
Growth Hormone Excess - Pathogenesis and clinical findings • Acromegaly and gigantism share the same pathophysiology
Overproduction #diagnosis ... #signs #symptoms ... #endocrinology
Polyarteritis Nodosa (PAN): Pathogenesis and Clinical Findings Medical Comorbidities Malignancies (most commonly hairy-cell leukemia) Immunogenetic Predisposition: patient is
necrotic purpura - Malignant ... Pathophysiology #Diagnosis ... #Signs #Symptoms
Chronic Hypertensive Retinopathy: Pathogenesis and clinical findings Ophthalmic Artery Hypertension Stage 1: Mild/vasoconstrictive • Acute and chronic vasospasm
Spots Stage 4: Malignant ... ophthalmology #diagnosis ... #signs #symptoms
Diffuse Systemic Sclerosis (Scleroderma) - Pulmonary Fibrosis -> Crackles, Abnormal CXR - Pulmonary Hypertension, Right Heart
> diarrhea - Malignant ... pathophysiology #signs #symptoms ... #diagnosis
Hydrocele: Pathogenesis and Clinical Findings Non-communicating: - Localized infection or trauma - Previous varicocelectomy or inguinal surgery
Testicular or scrotal malignancy ... Pathophysiology #Signs #Symptoms ... #Diagnosis #Urology
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