The Calgary Guide to Understanding Disease @TheCalgaryGuide
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Account created for The Calgary Guide to Understanding Disease - Linking pathophysiology to clinical presentation - http://calgaryguide.ucalgary.ca/
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diagnosis pathophysiology msk signs symptoms fractures achilles anterior antipsychotics bonetumors causes classification complications diabetes diabeticketoacidosis differential dislocation disruptors feedbackloop femoralhead
Diabetic Ketoacidosis (DKA) - Pathogenesis and Clinical Findings • Note: in DKA, body K+ is lost
Ketoacidosis (DKA ... Findings • Note: in DKA ... , body K+ is lost ... brain... thus, the body ... pathophysiology #endocrinology
Malignant Bone Tumors: Pathogenesis of X-ray appearance • Metastatic bone tumors (aka. cancerous cells from systemic
Malignant Bone Tumors ... • Metastatic bone ... tumors (aka. cancerous ... metastasized to the bone ... • Metastatic bone
Stress Fracture: Pathogenesis and clinical findings Abnormal biomechanics, Repetitive impact activities => Repetitive subthreshold mechanical loading => Bone strain =>
mechanical loading => Bone ... strain => Bone ... StressFractures #msk #orthopedics
Anterior Shoulder Dislocation: Pathogenesis, clinical, and radiographic findings Trauma, Fall on, outstretched arm, Overhead throwing => Abduction
and underlying bone ... joint capsule or bone ... symptoms #msk #orthopedics
Open Fractures: Mechanisms, Clinical Features and Complications Gustilo-Anderson Classification: • Type I - Wound <
soft tissue for bone ... Complications #MSK #Orthopedics
Feedback Loop: Growth Hormone (GH) Growth Hormone: • Liver -> GHR activates JAK-STAT pathway -> Incr IGF1
Incr IGF1 • Bone ... #FeedbackLoop #endocrinology
Subtrochanteric Femur Fracture: Pathogenesis and clinical findings • Subtrochanteric region spans 5 cm distally from the
Bisphosphonate suppresses bone ... damage weakens the bone ... Fractures #msk #orthopedics
Femoral Head Fracture: Pathogenesis and clinical findings • Posterior hip dislocation -> Impaction force from femoral
tear a portion of bone ... signs #symptoms #orthopedics
Achilles Tendon Rupture - Pathogenesis and clinical findings • The Achilles tendon is 15cm long in
tendon in the body ... pathophysiology #msk #orthopedics
Second Generation Antipsychotics: Mechanisms and Side Effects (Atypical Anti-Psychotics) - Examples: Clozapine, Olanzapine, Quetiapine, Risperidone, Zotepine, Paliperidone,
Block action of DA ... action throughout body ... action throughout body
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