The Calgary Guide to Understanding Disease @TheCalgaryGuide
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Major Depressive Disorder (MDD): Pathogenesis and Clinical Findings

Symptoms (included in DSM 5 criteria) - Present during
Clinical Findings Symptoms ... partum onset) - Anxiety ... features) #MDD #MajorDepressiveDisorder ... MoodDisorders #Diagnosis #Pathophysiology ... #Psychiatry
Post-Traumatic Stress Disorder (PTSD)
Neurochemical abnormalities
 • Hyper-vigilance
 • Emotional hyper-arousal
 • Exaggerated startle reflex
 • Anxiety
startle reflex • Anxiety ... BehavioralDisorder #Pathophysiology ... #diagnosis #symptoms ... #signs #psychiatry
Major Depressive Disorder: Complications
 • Recurrent Depressive Episodes
 • Early parenthood
 • Social isolation and interpersonal
dependence • Anxiety ... birth weight #MajorDepressiveDisorder ... Complications #Pathophysiology ... #Psychiatry
Alcohol Use Disorder: Pathogenesis and Clinical Findings

 • Tolerance (reduced sensitivity to effects of EtOH)
 •
• Withdrawal symptoms ... , seizure, and anxiety ... AlcoholUseDisorder #EtOH #Pathophysiology ... Diagnosis #Signs #Symptoms ... #Psychiatry
Diabetic Ketoacidosis (DKA) - Pathogenesis and Clinical Findings
 • Note: in DKA, body K+ is lost
Ketoacidosis (DKA ... Findings • Note: in DKA ... Signs/Symptoms/Complications ... #pathophysiology ... #endocrinology
Bipolar Disorder: Pathogenesis and Clinical Findings
 • Disruption of emotional homeostasis
 • Oscillation between mood states
- Incr guilt, anxiety ... MoodDisorders #Diagnosis #Pathophysiology ... #Signs #Symptoms ... #Psychiatry
Panic Disorder: Pathogenesis and clinical findings
Social Factors
 • Parenting and infant attachment
 • Childhood illness/abuse
 •
carrying anti-anxiety ... Anticipatory Anxiety ... PanicDisorder #Anxiety ... BehavioralDisorder #Pathophysiology ... #signs #psychiatry
Social Anxiety Disorder (SAD) - Pathophysiology 
Excessive fear of one or more social situations
 • Safety
Social Anxiety Disorder ... (SAD) - Pathophysiology ... of Anxiety: Mind ... BehavioralDisorder #SAD #Pathophysiology ... #signs #psychiatry
Oppositional Defiant Disorder (ODD): Pathogenesis and clinical findings
 - Must have >4 symptoms for >6 months,
- Must have >4 symptoms ... a sibling - Symptoms ... develop mood and anxiety ... BehavioralDisorder #Pathophysiology ... #signs #psychiatry
Anorexia Nervosa: Pathogenesis and Risk Factors
Biological Risk Factors
 • Gender: F > M
 • Genetics: concordance
Temperament: childhood anxiety ... AnorexiaNervosa #pathophysiology ... diagnosis #signs #symptoms ... #psychiatry #RiskFactors