The Calgary Guide to Understanding Disease @TheCalgaryGuide
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pathophysiology menstrualcycle ovariancycle diagnosis sideeffects antipsychotics pharmacology psychiatry feedbackloop comparison diabetes diabeticketoacidosis dysfunction erectile feedback firstgeneration follicularphase gh glftap growthhormone
Menstrual Cycle Physiology: Ovarian Cycle – Follicular Phase Explained Early Follicular Phase (Days 0-5) • Granulosa cells
production by pituitary ... back on anterior pituitary ... continue growing (mechanism ... growth (this is one mechanism ... FollicularPhase #endocrinology
Pituitary Mass Effects - Pathogenesis and Clinical Findings • Pituitary turnors are almost always a benign
Pituitary Mass Effects ... Pituitary adenomas ... Symptomatic pituitary ... • For pituitary ... #SideEffects #endocrinology
Menstrual Cycle Physiology: Ovarian Cycle – Brief Overview LH and FSH are required for follicular development and
- FSH from pituitary ... - LH from pituitary ... LH release from pituitary ... #menstruation #endocrinology
Menstrual Cycle Physiology: The Hypothalamic-Pituitary-Ovarian Axis Estrogen, when released: • Negatively feeds back on the hypothalamus and
The Hypothalamic-Pituitary-Ovarian ... hypothalamus and anterior pituitary ... hypothalamus and anterior pituitary ... HypothalamicPituitary #endocrinology
Diabetic Ketoacidosis (DKA) - Pathogenesis and Clinical Findings • Note: in DKA, body K+ is lost
Ketoacidosis (DKA ... Findings • Note: in DKA ... Treating DKA: 1) ... DiabeticKetoacidosis #DKA ... pathophysiology #endocrinology
Primary Hyperthyroidism - Pathogenesis and Clinical Findings Note: Although rare, gestational diseases can lead to thyrotoxicosis due
production by the pituitary ... Hyperthyroidism #endocrinology
Second Generation Antipsychotics: Mechanisms and Side Effects (Atypical Anti-Psychotics) - Examples: Clozapine, Olanzapine, Quetiapine, Risperidone, Zotepine, Paliperidone,
Antipsychotics: Mechanisms ... Block action of DA ... Cardio-metabolic effects - Mechanism ... SecondGeneration #Mechanisms
Feedback Loop: Prolactin (PRL) • PRL levels exhibit diurnal, menstrual, and age-related variation • TRH has
#FeedbackLoop #endocrinology ... pathophysiology #pituitary
Third Generation Antipsychotics: Mechanisms and Side Effects (Atypical Anti-Psychotics) Example: Aripiprazole Dopamine D2 Receptor Partial Agonist • Binds
Antipsychotics: Mechanisms ... Prevents excess DA ... and deficient DA ... ThirdGeneration #Mechanisms
Feedback Loop: Growth Hormone (GH) Growth Hormone: • Liver -> GHR activates JAK-STAT pathway -> Incr IGF1
#FeedbackLoop #endocrinology ... pathophysiology #pituitary
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