The Calgary Guide to Understanding Disease @TheCalgaryGuide
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Account created for The Calgary Guide to Understanding Disease - Linking pathophysiology to clinical presentation - http://calgaryguide.ucalgary.ca/
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Growth Hormone Excess - Pathogenesis and clinical findings
 • Acromegaly and gigantism share the same pathophysiology
GH excess prior ... GH excess after ... tolerance • Weight gain ... diagnosis #signs #symptoms ... #endocrinology
Feedback Loop: Growth Hormone (GH)
Growth Hormone:
 • Liver -> GHR activates JAK-STAT pathway -> Incr IGF1
Growth Hormone (GH ... lipolysis Signs/Symptoms ... : • GH deficiency ... abn lipid • GH ... #FeedbackLoop #endocrinology
Trendelenburg Gait: Pathogenesis and clinical findings

Skeletal Pathology of the Hip
 • Arthritis
 • Congenital hip dysplasia
Trendelenburg Gait ... Trendelenburg Gait ... Compensatory muscular dysfunction ... pathophysiology #causes #symptoms ... signs #diagnosis #msk
Meralgia paresthetica: Pathogenesis and Clinical Findings
Compression/injury of Lateral Femoral Cutaneous Nerve (LFCN) -> Meralgia paresthetica
 •
paresthetica • Symptoms ... 3-6 months of symptom ... abnormalities (gait ... mass Sensory Symptoms ... MeralgiaParesthetica #MSK
Serotonin-Norepinephrine Reuptake Inhibitors(SNRIs): Mechanisms and Side Effects

Withdrawal: Dizziness, Diarrhea, Insomnia, Nausea, Vomiting
Serotonin Syndrome - Potentially Life
Vertigo, Sexual Dysfunction ... , Weight gain Incr ... Diagnosis #Signs #Symptoms
Pituitary Mass Effects - Pathogenesis and Clinical Findings
 • Pituitary turnors are almost always a benign
following order; GH ... Signs / Symptoms ... • Hypothalamic dysfunction ... #SideEffects #endocrinology
Achilles Tendon Rupture - Pathogenesis and clinical findings
 • The Achilles tendon is 15cm long in
etiology Signs/Symptoms ... rupture - Antalgic gait ... diagnosis #signs #symptoms ... pathophysiology #msk
Cauda Equina Syndrome
Causes:
 • Large lumbar degenerative disc herniation (central)
 • Severe lumbar spondylosis
 • Neoplasm
spine Signs / Symptoms ... bladder/bowel dysfunction ... CaudaEquina #Syndrome #MSK ... pathophysiology #diagnosis #symptoms
Acute Spinal Cord Injuries: Pathogenesis and clinical findings
 • Anterior Cord Syndrome -> Anterior spinal artery
Upper Extremity Dysfunction ... deficiencies -> Sphincter dysfunction ... pathophysiology #signs #symptoms ... #msk #orthopedics
Paget’s Disease: Complications
Abnormal Osteoclasts cause excessive bone turnover -> Incr bone resorption, Incr (abnormal) bone formation

MSK
bone formation MSK ... causes middle ear dysfunction ... diagnosis #signs #symptoms