The Calgary Guide to Understanding Disease @TheCalgaryGuide
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Account created for The Calgary Guide to Understanding Disease - Linking pathophysiology to clinical presentation - http://calgaryguide.ucalgary.ca/
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menstrualcycle ovariancycle diagnosis symptoms feedbackloop growthhormone 21hydroxylasedeficiency 21ohd anxiety behavioraldisorder comparison diabetes diabeticketoacidosis endocin excess feedback follicularphase genetics glftap glucocorticoids
Feedback Loop: Growth Hormone (GH) Growth Hormone: • Liver -> GHR activates JAK-STAT pathway -> Incr IGF1
Growth Hormone (GH ... activates lipolysis Signs ... #FeedbackLoop #endocrinology ... #pathophysiology ... #pituitary
Growth Hormone Excess - Pathogenesis and clinical findings • Acromegaly and gigantism share the same pathophysiology
share the same pathophysiology ... GH excess prior ... Overproduction #diagnosis #signs ... #symptoms #endocrinology ... #pathophysiology
Pituitary Mass Effects - Pathogenesis and Clinical Findings • Pituitary turnors are almost always a benign
Pituitary Mass Effects ... following order; GH ... Signs / Symptoms ... #SideEffects #endocrinology ... mnemonic #GLFTAP #pathophysiology
Primary Hyperthyroidism - Pathogenesis and Clinical Findings Note: Although rare, gestational diseases can lead to thyrotoxicosis due
production by the pituitary ... Signs/Symptoms: ... Hyperthyroidism #endocrinology ... #pathophysiology
Menstrual Cycle Physiology: Ovarian Cycle – Brief Overview LH and FSH are required for follicular development and
- FSH from pituitary ... - LH from pituitary ... LH release from pituitary ... #OvarianCycle #pathophysiology ... #menstruation #endocrinology
Diabetic Ketoacidosis (DKA) - Pathogenesis and Clinical Findings • Note: in DKA, body K+ is lost
Ketoacidosis (DKA ... Findings • Note: in DKA ... Signs/Symptoms/Complications ... #pathophysiology ... #endocrinology
Menstrual Cycle Physiology: The Hypothalamic-Pituitary-Ovarian Axis Estrogen, when released: • Negatively feeds back on the hypothalamus and
The Hypothalamic-Pituitary-Ovarian ... hypothalamus and anterior pituitary ... hypothalamus and anterior pituitary ... MenstrualCycle #pathophysiology ... HypothalamicPituitary #endocrinology
Feedback Loop: Prolactin (PRL) • PRL levels exhibit diurnal, menstrual, and age-related variation • TRH has
#FeedbackLoop #endocrinology ... #pathophysiology ... #pituitary
Graves’ Disease: Pathogenesis and Clinical Findings B & T lymphocyte mediated autoimmunity attack TSH receptor -> Continuous
the etiology Signs ... GravesDisease #pathophysiology ... #endocin #endocrinology ... #symptoms #signs
Menstrual Cycle Physiology: Ovarian Cycle – Follicular Phase Explained Early Follicular Phase (Days 0-5) • Granulosa cells
production by pituitary ... back on anterior pituitary ... production by pituitary ... #OvarianCycle #pathophysiology ... FollicularPhase #endocrinology
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