The Calgary Guide to Understanding Disease @TheCalgaryGuide
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diagnosis signs complications vasculitis manifestations ophthalmology adhesivecapsulitis allergy ankylosingspondylitis arteritis arthropathy benign bph cascade centralretinalartery charcotjoint chondrocalcinosis cppd crao disease
Anaphylaxis: Pathogenesis Anaphylaxis is a Type 1 hypersensitivity reaction While the primary mechanism of anaphylaxis is mast cell
Anaphylaxis is ... production of inflammatory ... Recruitment of inflammatory ... #pathophysiology ... #immunology
Anaphylaxis: Signs and Symptoms Anaphylaxis: when any egg of three conditions is met: 1. Acute onset of skin/mucosal
Anaphylaxis: Signs ... and Symptoms Anaphylaxis ... Angioedema #Anaphylaxis ... #pathophysiology ... #immunology #diagnosis
X-Linked Agammaglobulinemia: Pathogenesis and clinical findings The epidemiology of this disease is 1/340,000 births and roughly double
X-Linked Agammaglobulinemia ... immunity Signs/Symptoms ... common antigens #Agammaglobulinemia ... #XLinked #pathophysiology ... #immunology
Inflammatory Cascade: Pathogenesis and Clinical Findings Continued Innate Immunity • Phagocytosis: (main mechanism) neutrophils and macrophages engulf
Inflammatory Cascade ... cell activity #Inflammatory ... #Inflammation #pathophysiology ... #immunology
Type I Hypersensitivity: Pathogenesis and clinical findings Definition: Production of lgE Antibodies that bind to harmless allergens
release the pro-inflammatory ... secretion • Inflammatory ... conjunctivitis • Anaphylaxis ... HypersensitivityReaction #Allergy #Immunology ... #pathophysiology
Anaphylaxis: Treatments (Acute) Additional Info: • IV steroids may be considered for prevention of late phase reactions.
Anaphylaxis: Treatments ... Ventolin inhaler #Anaphylaxis ... Treatments #Management #pathophysiology ... #immunology
Giant Cell (Temporal) Arteritis: Pathogenesis and investigations Risk Factors: - Unclear environmental triggers (may be viral, not
mutation) that alter inflammatory ... old; F>M Signs/Symptoms ... Temporal #Arteritis #Pathophysiology ... Diagnosis #Signs #Symptoms
Polyarteritis Nodosa (PAN): Pathogenesis and Clinical Findings Medical Comorbidities Malignancies (most commonly hairy-cell leukemia) Immunogenetic Predisposition: patient is
activating cellular inflammatory ... PolyarteritisNodosa #Pathophysiology ... Diagnosis #Signs #Symptoms
Adhesive Capsulitis (Frozen Shoulder) - Pathogenesis and Clinical Findings • Primary (Idiopathic): Unknown etiology, but associated
inflammation as post-inflammatory ... stop, but post-inflammatory ... FrozenShoulder #pathophysiology ... #diagnosis #symptoms
Lupus (SLE): Mucocutaneous Manifestations • Langerhan cells and keratinocytes release cytokines -> localized inflammatory response ->
cytokines -> localized inflammatory ... Manifestations #pathophysiology ... diagnosis #signs #symptoms
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