The Calgary Guide to Understanding Disease @TheCalgaryGuide
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Account created for The Calgary Guide to Understanding Disease - Linking pathophysiology to clinical presentation - http://calgaryguide.ucalgary.ca/
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diagnosis pathophysiology signs complications pharmacology sideeffects extraarticular inhibitors manifestations otitismedia ra rheumatoidarthritis anaphylaxis ankylosingspondylitis antipsychotics benign bph bulimianervosa cascade centralretinalartery
Inflammatory Cascade: Pathogenesis and Clinical Findings Continued Innate Immunity • Phagocytosis: (main mechanism) neutrophils and macrophages engulf
Phagocytosis: (main mechanism ... destruction), promote inflammation ... Inflammatory #Cascade #Inflammation ... pathophysiology #immunology
Anaphylaxis: Signs and Symptoms Anaphylaxis: when any egg of three conditions is met: 1. Acute onset of skin/mucosal
Anaphylaxis: Signs and Symptoms ... Acute onset of skin ... in the acute phase ... Signs / Symptoms ... pathophysiology #immunology
Selective Serotonin Reuptake Inhibitors: Mechanisms and Side Effects • Serotonin Syndrome: - Autonomic Hyperactivity:
Reuptake Inhibitors: Mechanisms ... #SideEffects #Psychiatry ... Diagnosis #Signs #Symptoms
Serotonin-Norepinephrine Reuptake Inhibitors(SNRIs): Mechanisms and Side Effects Withdrawal: Dizziness, Diarrhea, Insomnia, Nausea, Vomiting Serotonin Syndrome - Potentially Life
Inhibitors(SNRIs): Mechanisms ... #SideEffects #Psychiatry ... Diagnosis #Signs #Symptoms
First Generation Anti-Psychotics: Mechanisms and Side Effects Typical/Conventional Anti-Psychotics - Examples: Haloperidol, Chlorpromazine ACh M1 antagonist - Block
Anti-Psychotics: Mechanisms ... Extrapyramidal Symptoms ... bradykinesia/akinesia • Acute ... FirstGeneration #Mechanisms ... pharmacology #diagnosis #psychiatry
Rheumatoid arthritis (RA): Extra-articular manifestations Skin: • Inflammation of skin (esp. over areas of stress) forms
manifestations Skin: • Inflammation ... Eyes: • Globe inflammation ... on CXR • RA inflammation ... pulmonary fibrosis (mechanism ... pathophysiology #signs #symptoms
Acute Rheumatic Fever: Pathogenesis and Clinical Findings Delayed autoimmune reaction -> Molecular mimicry -> GAS antigen cross-reacts with host ->
Acute Rheumatic ... Tissue injury and inflammation ... , Carditis #Acute ... diagnosis #signs #symptoms
Acute Otitis Media: Pathogenesis and Clinical Findings (in Children) Upper Respiratory Tract Infection: - Bacterial: Streptococcus
Acute Otitis Media ... bacterial. => Inflammation ... slide for full mechanisms ... pathophysiology #diagnosis #symptoms
Lupus (SLE): Mucocutaneous Manifestations • Langerhan cells and keratinocytes release cytokines -> localized inflammatory response ->
scaling that extend inflammation ... -> Incr local inflammation ... follicles due to inflammation ... (complex mechanism ... diagnosis #signs #symptoms
Mastoiditis: Pathogenesis and clinical findings Acute or Chronic Otitis Media -> Stage 1: Hyperemeia of the mastoid
clinical findings Acute ... mastoid air cells (inflammation ... mucosa leads to inflammation ... mastoid air cells (inflammation ... pathophysiology #signs #symptoms
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