The Calgary Guide to Understanding Disease @TheCalgaryGuide
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Account created for The Calgary Guide to Understanding Disease - Linking pathophysiology to clinical presentation - http://calgaryguide.ucalgary.ca/
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pathophysiology diagnosis symptoms peds acute genetics geriatrics incontinence manifestations otitismedia urology 21hydroxylasedeficiency 21ohd alzheimersdisease anaphylaxis ankylosingspondylitis benign bph bulimianervosa cholesteatoma
Prader-Willi Syndrome: Pathogenesis and clinical findings • Maternal uniparental disomy: inheriting 2 copies of maternal chromosome
Prader-Willi Syndrome Signs ... /Symptoms/Complications ... : • Gonadal hypoplasia ... pathophysiology #peds #pediatrics
Anaphylaxis: Signs and Symptoms Anaphylaxis: when any egg of three conditions is met: 1. Acute onset of skin/mucosal
Anaphylaxis: Signs ... phase symptoms Signs ... / Symptoms / Complications ... pathophysiology #immunology ... #diagnosis #signs
Acute Otitis Media: Complications Infection and inflammation of the middle ear - Prolonged obstruction of e. tube
Otitis Media: Complications ... Infection and inflammation ... becomes more severe Signs ... /Symptoms/Complications ... pathophysiology #symptoms #signs
Retinoblastoma: Pathogenesis and clinical findings • Sporadic mutation -> One allele of RB1 tumor suppressor gene
Retinoblastoma Signs ... / Symptoms / Complications ... reflex) • Orbital inflammation ... ophthalmology #diagnosis #signs
21-Hydroxylase Deficiency (21-OHD): Pathogenesis and Clinical Findings Autosomal recessive mutation in CYP21A2 coding for the enzyme 21-OHase
congenital adrenal hyperplasia ... Signs/Symptoms/Complications ... endocrinology #peds #pediatrics
Acute Rheumatic Fever: Pathogenesis and Clinical Findings Delayed autoimmune reaction -> Molecular mimicry -> GAS antigen cross-reacts with host ->
Tissue injury and inflammation ... pathophysiology #diagnosis #signs ... #symptoms #complications
Fecal Incontinence - Pathogenesis and Complications Continence mechanisms are impaired • Local neuronal damage • External and
Pathogenesis and Complications ... Disorders • Inflammation ... #Incontinence #geriatrics
Acute Otitis Media: Pathogenesis and Clinical Findings (in Children) Upper Respiratory Tract Infection: - Bacterial: Streptococcus
. => Inflammation ... resolve by 72 hours Complications ... diagnosis #symptoms #signs ... #peds #pediatrics
Lupus (SLE): Mucocutaneous Manifestations • Langerhan cells and keratinocytes release cytokines -> localized inflammatory response ->
scaling that extend inflammation ... -> Incr local inflammation ... follicles due to inflammation ... pathophysiology #diagnosis #signs ... #symptoms #complications
Alzheimer’s Disease: Pathogenesis and Clinical Findings Risk factor for Late Onset Alzheimer's (99% of cases): - Increasing
chromosome 21) Signs ... / Symptoms / Complications ... pathophysiology #geriatrics ... #diagnosis #signs
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