The Calgary Guide to Understanding Disease @TheCalgaryGuide
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Inflammatory Cascade: Pathogenesis and Clinical Findings
Continued Innate Immunity
 • Phagocytosis: (main mechanism) neutrophils and macrophages engulf
Inflammatory Cascade ... destruction), promote inflammation ... cell activity #Inflammatory ... #Cascade #Inflammation ... pathophysiology #immunology
Lower Urinary Tract Infections: Complications
 - Infection damages the urinary tract epithelium causing fibroblast proliferation and
Tract Infections: Complications ... Bacterial toxins and inflammation ... in a systemic inflammatory ... Pathophysiology #Complications
Type I Hypersensitivity: Pathogenesis and clinical findings
Definition: Production of lgE Antibodies that bind to harmless allergens
release the pro-inflammatory ... secretion • Inflammatory ... cells recruited Complications ... HypersensitivityReaction #Allergy #Immunology
Lupus (SLE): Mucocutaneous Manifestations

 • Langerhan cells and keratinocytes release cytokines -> localized inflammatory response ->
cytokines -> localized inflammatory ... scaling that extend inflammation ... -> Incr local inflammation ... follicles due to inflammation ... signs #symptoms #complications
Mixed Urinary Incontinence: Pathogenesis and Clinical Findings

Urgency Urinary Incontinence (UUI) -> Urinary leakage preceded by a
tumour, stone, BPH ... (neurogenic), inflammation ... Incr PVR if a complication
Diabetic Foot: Pathogenesis and clinical findings
 • Polyol Pathway - Excess glucose enters Polyol pathway ->
dysfunction and inflammation ... arthropathy -> Localized inflammatory ... tissues results in inflammation ... pathophysiology #complications
Psoriatic Arthritis: Complications

 • Ocular - Inflammation of middle layer of the eye (the uvea, which
Psoriatic Arthritis: Complications ... • Ocular - Inflammation ... Valvular disease - Inflammatory ... WBCs activity -> inflammation ... signs #symptoms #Complications
Benign Prostatic Hyperplasia: Pathogenesis and Clinical Findings

Hormonal alterations (result of aging process)
    ->
FGF-related proteins) Inflammation ... granulocytes) -> Prostate Inflammation ... activation of inflammatory ... bladder stones #BPH
Ankylosing Spondylitis: Extra-articular Manifestations
 • Ocular - Inflammation of the iris, the anterior part of the
photophobia • GI - Inflammatory ... endoscopy (Not Inflammatory ... • Cardiac - Inflammation ... - Ligamentous inflammation ... Manifestations #Complications