The Calgary Guide to Understanding Disease @TheCalgaryGuide
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symptoms complications msk ophthalmology acute cellulitis disease extraarticular lupus manifestations otitismedia psoriaticarthritis psychiatry ra rheumatoidarthritis sle stages temporal urology adhesivecapsulitis
Lupus (SLE): Mucocutaneous Manifestations • Langerhan cells and keratinocytes release cytokines -> localized inflammatory response ->
cytokines -> localized inflammatory ... that extend inflammation ... Livedo Reticularis, Vasculitis ... Manifestations #pathophysiology ... #diagnosis #signs
Inflammatory Cascade: Pathogenesis and Clinical Findings Continued Innate Immunity • Phagocytosis: (main mechanism) neutrophils and macrophages engulf
Inflammatory Cascade ... destruction), promote inflammation ... #Cascade #Inflammation ... #pathophysiology ... #immunology
Giant Cell (Temporal) Arteritis: Pathogenesis and investigations Risk Factors: - Unclear environmental triggers (may be viral, not
mutation) that alter inflammatory ... yrs old; F>M Signs ... Temporal #Arteritis #Pathophysiology ... #Diagnosis #Signs ... #Symptoms #Vasculitis
Rheumatoid arthritis (RA): Extra-articular manifestations Skin: • Inflammation of skin (esp. over areas of stress) forms
blood vessels (vasculitis ... Eyes: • Globe inflammation ... RheumatoidArthritis #RA #pathophysiology ... #signs #symptoms ... #diagnosis #ExtraArticular
Systemic Lupus Erythematosus: Gastrointestinal Manifestations - Thrombosis of vessels in the pancreas, Vasculitis -> Acute Pancreatitis
the pancreas, Vasculitis ... Complications #pathophysiology ... #signs #symptoms ... #diagnosis
Anaphylaxis: Signs and Symptoms Anaphylaxis: when any egg of three conditions is met: 1. Acute onset of skin/mucosal
Anaphylaxis: Signs ... phase symptoms Signs ... #Anaphylaxis #pathophysiology ... #immunology #diagnosis ... #signs #symptoms
Radiculopathy: Signs and Symptoms • Back/Neck Pain • Decr Range of motion • Abnormal posturing •
Radiculopathy: Signs ... : -> Shooting, stabbing ... Radiculopathy #MSK #diagnosis ... #signs #symptoms ... #pathophysiology
Adhesive Capsulitis (Frozen Shoulder) - Pathogenesis and Clinical Findings • Primary (Idiopathic): Unknown etiology, but associated
as post-inflammatory ... FrozenShoulder #pathophysiology ... #diagnosis #symptoms ... #signs #stages ... #staging #msk
IgA Vasculitis – Henoch Scholein Purpura: Pathogenesis and Clinical Findings - Infectious Agents - 50% have
IgA Vasculitis – ... attraction of various inflammatory ... #HSP #IgA #Vasculitis ... HenochScholeinPurpura #Pathophysiology ... #Diagnosis #Signs
Polyarteritis Nodosa (PAN): Pathogenesis and Clinical Findings Medical Comorbidities Malignancies (most commonly hairy-cell leukemia) Immunogenetic Predisposition: patient is
activating cellular inflammatory ... PolyarteritisNodosa #Pathophysiology ... #Diagnosis #Signs ... #Symptoms #Vasculitis
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