The Calgary Guide to Understanding Disease @TheCalgaryGuide
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Account created for The Calgary Guide to Understanding Disease - Linking pathophysiology to clinical presentation - http://calgaryguide.ucalgary.ca/
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diagnosis signs complications manifestations otitismedia urology adhesivecapsulitis allergy anaphylaxis ankylosingspondylitis benign bph cascade centralretinalartery cholesteatoma chondrocalcinosis cppd crao disease extraarticular
Inflammatory Cascade: Pathogenesis and Clinical Findings Continued Innate Immunity • Phagocytosis: (main mechanism) neutrophils and macrophages engulf
Inflammatory Cascade ... destruction), promote inflammation ... #Cascade #Inflammation ... #pathophysiology ... #immunology
Anaphylaxis: Signs and Symptoms Anaphylaxis: when any egg of three conditions is met: 1. Acute onset of skin/mucosal
Anaphylaxis: Signs and Symptoms ... Acute onset of skin ... in the acute phase ... #Anaphylaxis #pathophysiology ... #immunology #diagnosis
Mixed Urinary Incontinence: Pathogenesis and Clinical Findings Urgency Urinary Incontinence (UUI) -> Urinary leakage preceded by a
Mixed Urinary Incontinence ... Urgency Urinary Incontinence ... (neurogenic), inflammation ... #Mixed #Pathophysiology ... #Signs #Symptoms
Acute Rheumatic Fever: Pathogenesis and Clinical Findings Delayed autoimmune reaction -> Molecular mimicry -> GAS antigen cross-reacts with host ->
Acute Rheumatic ... Tissue injury and inflammation ... , Carditis #Acute ... RheumaticFever #pathophysiology ... diagnosis #signs #symptoms
Benign Prostatic Hyperplasia: Pathogenesis and Clinical Findings Hormonal alterations (result of aging process) ->
FGF-related proteins) Inflammation ... activation of inflammatory ... Urgency, nocturia, incontinence ... Hydronephrosis, Acute ... Hyperplasia #Prostate #Pathophysiology
Mastoiditis: Pathogenesis and clinical findings Acute or Chronic Otitis Media -> Stage 1: Hyperemeia of the mastoid
clinical findings Acute ... mucosa leads to inflammation ... : Extension of inflammatory ... #Mastoiditis #pathophysiology ... #signs #symptoms
Lupus (SLE): Mucocutaneous Manifestations • Langerhan cells and keratinocytes release cytokines -> localized inflammatory response ->
cytokines -> localized inflammatory ... scaling that extend inflammation ... -> Incr local inflammation ... Manifestations #pathophysiology ... diagnosis #signs #symptoms
Type I Hypersensitivity: Pathogenesis and clinical findings Definition: Production of lgE Antibodies that bind to harmless allergens
release the pro-inflammatory ... secretion • Inflammatory ... Complications: • Acute ... HypersensitivityReaction #Allergy #Immunology ... #pathophysiology
Ankylosing Spondylitis: Extra-articular Manifestations • Ocular - Inflammation of the iris, the anterior part of the
endoscopy (Not Inflammatory ... acute phase reactant ... Bladder and bowel incontinence ... Complications #pathophysiology ... diagnosis #signs #symptoms
Acute Otitis Media: Complications Infection and inflammation of the middle ear - Prolonged obstruction of e. tube
Acute Otitis Media ... Infection and inflammation ... severe Signs/Symptoms ... Complications #pathophysiology ... #symptoms #signs
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