The Calgary Guide to Understanding Disease @TheCalgaryGuide
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Account created for The Calgary Guide to Understanding Disease - Linking pathophysiology to clinical presentation - http://calgaryguide.ucalgary.ca/
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Type I Hypersensitivity: Pathogenesis and clinical findings
Definition: Production of lgE Antibodies that bind to harmless allergens
leading to an allergic ... release the pro-inflammatory ... secretion • Inflammatory ... Complications: • Acute ... #Immunology #pathophysiology
Anaphylaxis: Signs and Symptoms
Anaphylaxis: when any egg of three conditions is met:
1. Acute onset of skin/mucosal
Acute onset of skin ... exposure to known allergen ... in the acute phase ... #Anaphylaxis #pathophysiology ... #immunology #diagnosis
Mixed Urinary Incontinence: Pathogenesis and Clinical Findings

Urgency Urinary Incontinence (UUI) -> Urinary leakage preceded by a
Mixed Urinary Incontinence ... (neurogenic), inflammation ... #Mixed #Pathophysiology ... #Signs #Symptoms ... #Urology #Diagnosis
Acute Rheumatic Fever: Pathogenesis and Clinical Findings

Delayed autoimmune reaction
-> Molecular mimicry
-> GAS antigen cross-reacts with host
->
Acute Rheumatic ... Tissue injury and inflammation ... RheumaticFever #pathophysiology ... #diagnosis #signs ... #symptoms #complications
Mastoiditis: Pathogenesis and clinical findings

Acute or Chronic Otitis Media -> 
Stage 1: Hyperemeia of the mastoid
clinical findings Acute ... : Extension of inflammatory ... #Mastoiditis #pathophysiology ... #signs #symptoms ... #diagnosis #otology
Benign Prostatic Hyperplasia: Pathogenesis and Clinical Findings

Hormonal alterations (result of aging process)
    ->
activation of inflammatory ... Urgency, nocturia, incontinence ... Hydronephrosis, Acute ... Hyperplasia #Prostate #Pathophysiology ... #Diagnosis
Lupus (SLE): Mucocutaneous Manifestations

 • Langerhan cells and keratinocytes release cytokines -> localized inflammatory response ->
cytokines -> localized inflammatory ... -> Incr local inflammation ... Manifestations #pathophysiology ... #diagnosis #signs ... #symptoms #complications
Ankylosing Spondylitis: Extra-articular Manifestations
 • Ocular - Inflammation of the iris, the anterior part of the
acute phase reactant ... Bladder and bowel incontinence ... Complications #pathophysiology ... #diagnosis #signs ... #symptoms
Acute Otitis Media: Complications
Infection and inflammation of the middle ear
 - Prolonged obstruction of e. tube
Acute Otitis Media ... Infection and inflammation ... Complications #pathophysiology ... #symptoms #signs ... #diagnosis
Adhesive Capsulitis (Frozen Shoulder) - Pathogenesis and Clinical Findings

 • Primary (Idiopathic): Unknown etiology, but associated
shoulder joint inflammation ... as post-inflammatory ... shoulder joint inflammation ... FrozenShoulder #pathophysiology ... #diagnosis #symptoms