The Calgary Guide to Understanding Disease @TheCalgaryGuide
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pathophysiology diagnosis signs manifestations acute ankylosingspondylitis cholesteatoma extraarticular lupus middleear mucocutaneous otology pediatrics peds psoriaticarthritis sle
Inflammatory Cascade: Pathogenesis and Clinical Findings Continued Innate Immunity • Phagocytosis: (main mechanism) neutrophils and macrophages engulf
Inflammatory Cascade ... destruction), promote inflammation ... cell activity #Inflammatory ... #Cascade #Inflammation ... pathophysiology #immunology
Acute Otitis Media: Complications Infection and inflammation of the middle ear - Prolonged obstruction of e. tube
Infection and inflammation ... severe Signs/Symptoms ... sensorineural is rare • Mastoiditis ... Problems #Acute #OtitisMedia ... pathophysiology #symptoms
Acute Otitis Media: Pathogenesis and Clinical Findings (in Children) Upper Respiratory Tract Infection: - Bacterial: Streptococcus
. => Inflammation ... resolve by 72 hours Complications ... hearing loss, mastoiditis ... mechanisms) #OtitisMedia ... pathophysiology #diagnosis #symptoms
Mastoiditis: Pathogenesis and clinical findings Acute or Chronic Otitis Media -> Stage 1: Hyperemeia of the mastoid
Mastoiditis: Pathogenesis ... mucosa leads to inflammation ... : Extension of inflammatory ... abscesses #Mastoiditis ... pathophysiology #signs #symptoms
Lupus (SLE): Mucocutaneous Manifestations • Langerhan cells and keratinocytes release cytokines -> localized inflammatory response ->
cytokines -> localized inflammatory ... scaling that extend inflammation ... -> Incr local inflammation ... diagnosis #signs #symptoms ... #complications
Psoriatic Arthritis: Complications • Ocular - Inflammation of middle layer of the eye (the uvea, which
Psoriatic Arthritis: Complications ... • Ocular - Inflammation ... Valvular disease - Inflammatory ... diagnosis #signs #symptoms ... #Complications
Cholesteatoma (of middle ear): Pathogenesis and clinical findings • Congenital trapping of keratinizing epithelium in middle
middle ear Signs / Symptoms ... / Complications ... Polyp secondary to inflammation ... • Coalescent Mastoiditis ... pathophysiology #symptoms
Ankylosing Spondylitis: Extra-articular Manifestations • Ocular - Inflammation of the iris, the anterior part of the
photophobia • GI - Inflammatory ... endoscopy (Not Inflammatory ... • Cardiac - Inflammation ... Manifestations #Complications ... diagnosis #signs #symptoms
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