The Calgary Guide to Understanding Disease @TheCalgaryGuide
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Retroviral Infections: Mechanisms of Oncogenesis
Note: A retrovirus is an RNA virus that uses reverse transcriptase to
Retroviral Infections ... Oncogenesis Note: A retrovirus ... Examples of retrovirus-associated ... /leukemia) #Retroviral ... pathophysiology #immunology
X-linked Severe Combined Immunodeficiency (SCID): Pathogenesis and clinical findings

#SCID #SevereCombinedImmunodeficiency #XLinked #pathophysiology #immunology
Immunodeficiency (SCID ... clinical findings #SCID ... pathophysiology #immunology
Type III Hypersensitivity: Pathogenesis and clinical findings
Definition: Small antigen-antibody complexes (produced from normal immune response to
HypersensitivityReaction #Allergy #Immunology
Inflammatory Cascade: Pathogenesis and Clinical Findings
Continued Innate Immunity
 • Phagocytosis: (main mechanism) neutrophils and macrophages engulf
pathophysiology #immunology
Anaphylaxis: Pathogenesis
Anaphylaxis is a Type 1 hypersensitivity reaction
While the primary mechanism of anaphylaxis is mast cell
pathophysiology #immunology
Anaphylaxis: Signs and Symptoms
Anaphylaxis: when any egg of three conditions is met:
1. Acute onset of skin/mucosal
pathophysiology #immunology
Type IV Hypersensitivity: Pathogenesis and clinical findings
Definition: Unique because it is entirely T-Cell mediated; exposure to
HypersensitivityReaction #Allergy #Immunology
Hyperuricemia: Pathogenesis and Complications

 - Hypercalcemia (due to diseases like Sarcoidosis and Hyperparathyroidism) -> Accumulation of
to filter uric acid ... acids like lactic acid ... secretion of uric acid ... Under-excretion of Uric Acid ... abnormally high uric acid
Gout: Pathogenesis and Clinical Findings
 - Conditions of rapid cell turnover: hemolysis, psoriasis, lymphoproliferative disorders
 -
ketones and lactic acid ... compete with uric acid ... excretion of uric acid ... -> Incr uric acid ... joints -> Uric acid
Type II Hypersensitivity: Pathogenesis and clinical findings
Definition: When antigens bind to the body's cell surfaces, forming
HypersensitivityReaction #Allergy #Immunology