The Calgary Guide to Understanding Disease @TheCalgaryGuide
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Account created for The Calgary Guide to Understanding Disease - Linking pathophysiology to clinical presentation - http://calgaryguide.ucalgary.ca/
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pathophysiology diagnosis signs orthopedics ankylosingspondylitis anorexianervosa femoralhead genetics gustiloanderson open pagetsdisease pediatrics peds pelvicring praderwilli psychiatry stressfractures syndrome
Classification of Pelvic Ring Fractures: Mechanisms, Clinical Features and Complications • Anterior Posterior Compression (APC) -
Pelvic Ring Fractures ... bilateral rami fractures ... 2 - Rami fracture ... #Grades #Grading ... #Orthopedics #MSK
Stress Fracture: Pathogenesis and clinical findings Abnormal biomechanics, Repetitive impact activities => Repetitive subthreshold mechanical loading => Bone strain =>
Stress Fracture: ... => Microscopic fractures ... => Fracture propagation ... Stress Fracture ... StressFractures #msk
Open Fractures: Mechanisms, Clinical Features and Complications Gustilo-Anderson Classification: • Type I - Wound <
Open Fractures: ... and Complications ... Gustilo-Anderson Classification ... #Open #Fractures ... #MSK #Orthopedics
Femoral Head Fracture: Pathogenesis and clinical findings • Posterior hip dislocation -> Impaction force from femoral
Femoral Head Fracture ... /Complications: ... • Non-union of fracture ... #FemoralHead #Fractures ... #msk #diagnosis
Prader-Willi Syndrome: Pathogenesis and clinical findings • Maternal uniparental disomy: inheriting 2 copies of maternal chromosome
Prader-Willi Syndrome ... hypothalamus =>Prader-Willi ... Syndrome Signs/Symptoms ... /Complications: ... Incr Skeletal fractures
Ankylosing Spondylitis: Pathogenesis and Clinical findings • Pain in lumbar area and gluteal region: (Dull, insidious
prominently in Achilles ... column) • Late complication ... bamboo spine) -> Fracture ... diagnosis #signs #symptoms
Paget’s Disease: Complications Abnormal Osteoclasts cause excessive bone turnover -> Incr bone resorption, Incr (abnormal) bone formation MSK
Paget’s Disease: Complications ... bone formation MSK ... -> Pathologic fractures ... diagnosis #signs #symptoms ... #complications
Anorexia Nervosa: Complications CARDIAC ABNORMALITIES - Functional: Low BP, Sinus bradycardia, prolonged QT interval - Structural: Reduced
Anorexia Nervosa: Complications ... increased risk of fracture ... Death - Cardiac complications ... highest mortality rates ... diagnosis #signs #symptoms
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