The Calgary Guide to Understanding Disease @TheCalgaryGuide
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Account created for The Calgary Guide to Understanding Disease - Linking pathophysiology to clinical presentation - http://calgaryguide.ucalgary.ca/
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Stress Fracture: Pathogenesis and clinical findings
Abnormal biomechanics, Repetitive impact activities
=> Repetitive subthreshold mechanical loading
=> Bone strain
=>
Stress Fracture: ... Pathogenesis and clinical ... => Microscopic fractures ... StressFractures #msk ... pathophysiology #symptoms
Subtrochanteric Femur Fracture: Pathogenesis and clinical findings
 • Subtrochanteric region spans 5 cm distally from the
Subtrochanteric Femur Fracture ... Pathogenesis and clinical ... in elderly Causes ... #msk #orthopedics ... #differential #causes
Femoral Head Fracture: Pathogenesis and clinical findings
 • Posterior hip dislocation -> Impaction force from femoral
Femoral Head Fracture ... Pathogenesis and clinical ... lateral hip Signs/Symptoms ... #msk #diagnosis ... pathophysiology #signs #symptoms
Spondylolysis & Spondylolisthesis: Pathogenesis and Clinical Findings

Pars interarticularis stress fracture (spondylolysis) - most frequently in the
Pathogenesis and Clinical ... interarticularis stress fracture ... Spondylolisthesis #MSK ... pathophysiology #signs #symptoms
Trendelenburg Gait: Pathogenesis and clinical findings

Skeletal Pathology of the Hip
 • Arthritis
 • Congenital hip dysplasia
Pathogenesis and clinical ... Greater Trochanter Fracture ... pathophysiology #causes ... #symptoms #signs ... #diagnosis #msk
Paget’s Disease: Pathogenesis and Clinical Findings

 • Incr serum CTx - marker of bone resorption
 •
Pathogenesis and Clinical ... , kyphosis and fractures ... formation #PagetsDisease ... diagnosis #signs #symptoms
Paget’s Disease: Complications
Abnormal Osteoclasts cause excessive bone turnover -> Incr bone resorption, Incr (abnormal) bone formation

MSK
Abnormal Osteoclasts cause ... bone formation MSK ... -> Pathologic fractures ... hearing loss #PagetsDisease ... diagnosis #signs #symptoms
Growth Hormone Excess - Pathogenesis and clinical findings
 • Acromegaly and gigantism share the same pathophysiology
Pathogenesis and clinical ... • Other rare causes ... Acne • Coarse features ... diagnosis #signs #symptoms
Adhesive Capsulitis (Frozen Shoulder) - Pathogenesis and Clinical Findings

 • Primary (Idiopathic): Unknown etiology, but associated
Pathogenesis and Clinical ... , humeral head fracture ... a stroke that caused ... pathophysiology #diagnosis #symptoms ... stages #staging #msk
Serotonin Syndrome: Pathogenesis and Clinical Findings
Serotonin Syndrome: Variable combination of mental status changes, autonomic instability, and
Pathogenesis and Clinical ... ingestion and most cases ... used to make a clinical ... features: - Spontaneous ... Diagnosis #Signs #Symptoms