The Calgary Guide to Understanding Disease @TheCalgaryGuide
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Account created for The Calgary Guide to Understanding Disease - Linking pathophysiology to clinical presentation - http://calgaryguide.ucalgary.ca/
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diagnosis signs symptoms psychiatry pharmacology inhibitors lupus ophthalmology serotonin sle acute adhesivecapsulitis alcohol allergy alzheimersdisease anticonvulsants bulimianervosa caudaequina cecs chronic
Cauda Equina Syndrome Causes: • Large lumbar degenerative disc herniation (central) • Severe lumbar spondylosis • Neoplasm
Cauda Equina Syndrome ... Causes: • Large ... Signs / Symptoms / Complications ... pain (shooting, stabbing ... #MSK #pathophysiology
Selective Serotonin Reuptake Inhibitors: Mechanisms and Side Effects • Serotonin Syndrome: - Autonomic Hyperactivity:
• Serotonin Syndrome ... SSRI Withdrawal Syndrome ... Dizziness - Nausea ... Serotonin #Inhibitors #Pathophysiology ... #Pharmacology #SideEffects
Disc Herniations - Pathogenesis and Complications • 90% of Lumbar disc herniations happen at L4/5 and L5/S1 •
Pathogenesis and Complications ... happen at C6/7 Aging ... DiscHerniations #complications ... #msk #pathophysiology
Serotonin-Norepinephrine Reuptake Inhibitors(SNRIs): Mechanisms and Side Effects Withdrawal: Dizziness, Diarrhea, Insomnia, Nausea, Vomiting Serotonin Syndrome - Potentially Life
Diarrhea, Insomnia, Nausea ... Vomiting Serotonin Syndrome ... gain Incr NE: Nausea ... SerotoninNorepinephrine #Inhibitors #Pathophysiology ... #Pharmacology #SideEffects
Systemic Lupus Erythematosus (SLE): Musculoskeletal Manifestations • Immune Complex Deposition - Arthralgia, Arthritis
Myopathy (Also caused ... Erythematosus #SLE #MSK ... Musculoskeletal #Complications ... #pathophysiology
Adhesive Capsulitis (Frozen Shoulder) - Pathogenesis and Clinical Findings • Primary (Idiopathic): Unknown etiology, but associated
a stroke that caused ... side) Second Stage ... movement) Third Stage ... FrozenShoulder #pathophysiology ... #staging #msk
Chronic Hypertensive Retinopathy: Pathogenesis and clinical findings Ophthalmic Artery Hypertension Stage 1: Mild/vasoconstrictive • Acute and chronic vasospasm
Hypertension Stage ... vascular tortuosity Stage ... -> AV nicking Stage ... #Retinopathy #pathophysiology ... signs #symptoms #complications
Lower Urinary Tract Infections: Complications - Infection damages the urinary tract epithelium causing fibroblast proliferation and
Tract Infections: Complications ... urea which may cause ... urine -> Struvite stones ... UrinaryTractInfection #LUTI #Pathophysiology ... #Complications
Anticonvulsants as Mood Stabilizers: Mechanism and Side-effect Examples: Valproate, Carbamazepine, Lamotrigine • Mild anticholinergic effect -> Drowsiness
Stevens-Johnson Syndrome ... Systemic effect -> Nausea ... MoodStabilizers #Mechanism #SideEffects ... #Pathophysiology
Lupus (SLE): Mucocutaneous Manifestations • Langerhan cells and keratinocytes release cytokines -> localized inflammatory response ->
exposed areas -> Scaring ... with keratotic scaling ... hair follicles -> causes ... Manifestations #pathophysiology ... signs #symptoms #complications
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