The Calgary Guide to Understanding Disease @TheCalgaryGuide
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Account created for The Calgary Guide to Understanding Disease - Linking pathophysiology to clinical presentation - http://calgaryguide.ucalgary.ca/
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pathophysiology diagnosis symptoms complications stages staging adhesivecapsulitis alcoholusedisorder bulimianervosa diabetic diabeticfoot disruptors etoh femoralhead fracture fractures frozenshoulder grades lowanklesprain ophthalmology
Low Ankle Sprain: Pathomechanics and Clinical Findings Grading Ligament Sprains l: Minimal ligament disruption, mild swelling & tenderness,
Clinical Findings Grading ... ligament substance leading ... ligament substance leading ... LowAnkleSprain #Sports #MSK ... #orthopedics #Grading
Stress Fracture: Pathogenesis and clinical findings Abnormal biomechanics, Repetitive impact activities => Repetitive subthreshold mechanical loading => Bone strain =>
subthreshold mechanical loading ... from continued loading ... StressFractures #msk ... #orthopedics #pathophysiology ... #symptoms #signs
Diabetic Retinopathy: Pathogenesis and clinical findings Mild Non-proliferative DR • Outpouchings of the weakened capillary walls or
Diabetic Retinopathy ... other proteins leaking ... ischemia -> Venous beading ... retinal ischemia causes ... #Retinopathy #Diabetes
Femoral Head Fracture: Pathogenesis and clinical findings • Posterior hip dislocation -> Impaction force from femoral
• Avulsion or shearing ... onto lateral hip Signs ... FemoralHead #Fractures #msk ... pathophysiology #signs ... #symptoms #orthopedics
Diabetic Foot: Pathogenesis and clinical findings • Polyol Pathway - Excess glucose enters Polyol pathway ->
Diabetic Foot: Pathogenesis ... Glycosylation - AGE cause ... neuropathy => Diabetic ... in inopportune loading ... Healing is impaired
Adhesive Capsulitis (Frozen Shoulder) - Pathogenesis and Clinical Findings • Primary (Idiopathic): Unknown etiology, but associated
autoimmune disorders (diabetes ... a stroke that caused ... post-inflammatory healing ... diagnosis #symptoms #signs ... stages #staging #msk
Alcohol Use Disorder: Pathogenesis and Clinical Findings • Tolerance (reduced sensitivity to effects of EtOH) •
- Alcohol craving ... , tachycardia, nausea ... Pathophysiology #Diagnosis #Signs ... #Symptoms #Psychiatry
Bulimia Nervosa: Signs and Symptoms Associated Psychological / Behavioural Features • Feelings of shame, guilt and embarrassment
Bulimia Nervosa: Signs ... Secrecy surrounding eating ... frequent urination (diabetes ... Sores, scars, calluses ... #symptoms #psychiatry
Fracture Healing (and disruptors of this process) Inflammatory Stage (0-7d) • Fracture disrupts local blood vessels ->
Fracture Healing ... Fluoroquinolones - Causes ... #Fracture #Healing ... #Stages #Orthopedics ... #msk #Staging #
Paget’s Disease: Complications Abnormal Osteoclasts cause excessive bone turnover -> Incr bone resorption, Incr (abnormal) bone formation MSK
Abnormal Osteoclasts cause ... bone formation MSK ... Skull expansion causes ... -> Conductive hearing ... pathophysiology #diagnosis #signs
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