The Calgary Guide to Understanding Disease @TheCalgaryGuide
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Account created for The Calgary Guide to Understanding Disease - Linking pathophysiology to clinical presentation - http://calgaryguide.ucalgary.ca/
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Post-Traumatic Stress Disorder (PTSD)
Neurochemical abnormalities
 • Hyper-vigilance
 • Emotional hyper-arousal
 • Exaggerated startle reflex
 • Anxiety
startle reflex • Anxiety ... StressDisorder #PTSD #BehavioralDisorder ... diagnosis #symptoms #signs
Stress Fracture: Pathogenesis and clinical findings
Abnormal biomechanics, Repetitive impact activities
=> Repetitive subthreshold mechanical loading
=> Bone strain
=>
subthreshold mechanical loading ... from continued loading ... StressFractures #msk ... pathophysiology #symptoms #signs
Patellofemoral Syndrome - Pathogenesis and clinical findings
 • Anterior Knee Pain with possible symptoms of 'catching'
pain • Palpable grinding ... pathophysiology #diagnosis #signs ... #symptoms #msk
Panic Disorder: Pathogenesis and clinical findings
Social Factors
 • Parenting and infant attachment
 • Childhood illness/abuse
 •
carrying anti-anxiety ... Anticipatory Anxiety ... PanicDisorder #Anxiety ... #BehavioralDisorder ... diagnosis #symptoms #signs
Alcohol Use Disorder: Pathogenesis and Clinical Findings

 • Tolerance (reduced sensitivity to effects of EtOH)
 •
- Alcohol craving ... , seizure, and anxiety ... Pathophysiology #Diagnosis #Signs
Bipolar Disorder: Pathogenesis and Clinical Findings
 • Disruption of emotional homeostasis
 • Oscillation between mood states
distractibility - racing ... - Incr guilt, anxiety ... Pathophysiology #Signs
Social Anxiety Disorder (SAD) - Pathophysiology 
Excessive fear of one or more social situations
 • Safety
Social Anxiety Disorder ... reduce social anxiety ... Physical Symptoms of Anxiety ... SocialAnxiety #BehavioralDisorder ... diagnosis #symptoms #signs
Oppositional Defiant Disorder (ODD): Pathogenesis and clinical findings
 - Must have >4 symptoms for >6 months,
develop mood and anxiety ... OppositionalDefiant #ODD #BehavioralDisorder ... diagnosis #symptoms #signs