The Calgary Guide to Understanding Disease @TheCalgaryGuide
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Account created for The Calgary Guide to Understanding Disease - Linking pathophysiology to clinical presentation - http://calgaryguide.ucalgary.ca/
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pathophysiology diagnosis orthopedics achilles anorexianervosa causes endocrinology femoralhead gh growthhormone osteomalacia overproduction pagetsdisease psychiatry rickets stressfractures tendonrupture trendelenburg
Stress Fracture: Pathogenesis and clinical findings Abnormal biomechanics, Repetitive impact activities => Repetitive subthreshold mechanical loading => Bone strain =>
Stress Fracture: ... Accumulated micro-damage exceeds ... StressFractures #msk ... pathophysiology #symptoms ... #signs
Femoral Head Fracture: Pathogenesis and clinical findings • Posterior hip dislocation -> Impaction force from femoral
onto lateral hip Signs ... /Symptoms/Complications ... #msk #diagnosis ... pathophysiology #signs ... #symptoms #orthopedics
Ankylosing Spondylitis: Pathogenesis and Clinical findings • Pain in lumbar area and gluteal region: (Dull, insidious
column) • Late complication ... bamboo spine) -> Fracture ... minor trauma #AnkylosingSpondylitis ... pathophysiology #diagnosis #signs ... #symptoms
Growth Hormone Excess - Pathogenesis and clinical findings • Acromegaly and gigantism share the same pathophysiology
Growth Hormone Excess ... Acne • Coarse features ... tolerance • Weight gain ... Overproduction #diagnosis #signs ... #symptoms #endocrinology
Achilles Tendon Rupture - Pathogenesis and clinical findings • The Achilles tendon is 15cm long in
pre-determined etiology Signs ... /Symptoms/Complications ... rupture - Antalgic gait ... #symptoms #pathophysiology ... #msk #orthopedics
Trendelenburg Gait: Pathogenesis and clinical findings Skeletal Pathology of the Hip • Arthritis • Congenital hip dysplasia
Trendelenburg Gait ... Greater Trochanter Fracture ... pathophysiology #causes #symptoms ... #signs #diagnosis ... #msk
Rickets and Osteomalacia: Pathogenesis and Clinical Findings • Calcification inhibitors (excess exposure to A1, Fluoride, etidronate)
Calcification inhibitors (excess ... Bowed legs • Fractures ... manifesting often as gait ... pathophysiology #diagnosis #signs ... #symptoms
Anorexia Nervosa: Complications CARDIAC ABNORMALITIES - Functional: Low BP, Sinus bradycardia, prolonged QT interval - Structural: Reduced
Anorexia Nervosa: Complications ... increased risk of fracture ... - Lethargy or Excess ... pathophysiology #diagnosis #signs ... #symptoms #psychiatry
Paget’s Disease: Complications Abnormal Osteoclasts cause excessive bone turnover -> Incr bone resorption, Incr (abnormal) bone formation MSK
Paget’s Disease: Complications ... bone formation MSK ... -> Pathologic fractures ... pathophysiology #diagnosis #signs ... #symptoms #complications
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