The Calgary Guide to Understanding Disease @TheCalgaryGuide
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Account created for The Calgary Guide to Understanding Disease - Linking pathophysiology to clinical presentation - http://calgaryguide.ucalgary.ca/
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Meralgia paresthetica: Pathogenesis and Clinical Findings
Compression/injury of Lateral Femoral Cutaneous Nerve (LFCN) -> Meralgia paresthetica
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Findings Compression/injury ... Cutaneous Nerve (LFCN ... MeralgiaParesthetica #MSK ... #pathophysiology ... differential #diagnosis #signs
Acute Spinal Cord Injuries: Pathogenesis and clinical findings
 • Anterior Cord Syndrome -> Anterior spinal artery
spinal artery injury ... function below injury ... Syndromes #diagnosis #pathophysiology ... #signs #symptoms ... #msk #orthopedics
RICE: Mechanism of Action
Rest (weight bearing or stressful motion discontinued)
Ice (applied to injury)
Compression (wrap applied to
RICE: Mechanism ... Ice (applied to injury ... wrap applied to injured ... #RICE #Sports #pathophysiology ... #mechanism #MSK
Femoral Head Fracture: Pathogenesis and clinical findings
 • Posterior hip dislocation -> Impaction force from femoral
Avulsion or shearing injury ... onto lateral hip Signs ... FemoralHead #Fractures #msk ... #diagnosis #pathophysiology ... #signs #symptoms
Shoulder Impingement Syndrome (SIS): Signs and Symptoms

Repetitive Overhead Activity, Scapular Dyskinesis -> Scapulohumeral mechanics become altered
Syndrome (SIS): Signs ... Scapulohumeral mechanics ... SIS #diagnosis #signs ... #symptoms #msk ... #pathophysiology
Polyarteritis Nodosa (PAN): Pathogenesis and Clinical Findings

Medical Comorbidities Malignancies (most commonly hairy-cell leukemia)
Immunogenetic Predisposition: patient is
causes direct injury ... PolyarteritisNodosa #Pathophysiology ... #Diagnosis #Signs ... #Symptoms #Vasculitis
Rheumatoid arthritis (RA): Extra-articular manifestations
Skin: 
 • Inflammation of skin (esp. over areas of stress) forms
blood vessels (vasculitis ... pulmonary fibrosis (mechanism ... RheumatoidArthritis #RA #pathophysiology ... #signs #symptoms
Lupus (SLE): Mucocutaneous Manifestations

 • Langerhan cells and keratinocytes release cytokines -> localized inflammatory response ->
inflammation (complex mechanism ... Livedo Reticularis, Vasculitis ... Manifestations #pathophysiology ... #diagnosis #signs
Classification of Pelvic Ring Fractures: Mechanisms, Clinical Features and Complications
 • Anterior Posterior Compression (APC) -
Ring Fractures: Mechanisms ... possible vascular injury ... - Type 1 or 2 injury ... #Orthopedics #MSK ... complications #pathophysiology
Adhesive Capsulitis (Frozen Shoulder) - Pathogenesis and Clinical Findings

 • Primary (Idiopathic): Unknown etiology, but associated
Prolonged shoulder injury ... FrozenShoulder #pathophysiology ... diagnosis #symptoms #signs ... stages #staging #msk