The Calgary Guide to Understanding Disease @TheCalgaryGuide
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Account created for The Calgary Guide to Understanding Disease - Linking pathophysiology to clinical presentation - http://calgaryguide.ucalgary.ca/
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Stress Fracture: Pathogenesis and clinical findings
Abnormal biomechanics, Repetitive impact activities
=> Repetitive subthreshold mechanical loading
=> Bone strain
=>
Stress Fracture: ... => Microscopic fractures ... => Fracture propagation ... loading Stress Fracture ... pathophysiology #symptoms #signs
Classification of Pelvic Ring Fractures: Mechanisms, Clinical Features and Complications
 • Anterior Posterior Compression (APC) -
Pelvic Ring Fractures ... Sacral compression fracture ... Grade 2 - Rami fracture ... #PelvicRing #Fractures ... Grades #Grading #Orthopedics
Femoral Head Fracture: Pathogenesis and clinical findings
 • Posterior hip dislocation -> Impaction force from femoral
Femoral Head Fracture ... • Avulsion or shearing ... • Non-union of fracture ... #FemoralHead #Fractures ... #symptoms #orthopedics
Open Fractures: Mechanisms, Clinical Features and Complications
Gustilo-Anderson Classification:
 • Type I
   - Wound <
Open Fractures: ... Gustilo-Anderson Classification ... GustiloAnderson #Classification ... #Open #Fractures ... Complications #MSK #Orthopedics
Fracture Healing (and disruptors of this process)
Inflammatory Stage (0-7d)
 • Fracture disrupts local blood vessels ->
Fracture Healing ... Stage (0-7d) • Fracture ... chondrocytes at fracture ... #Fracture #Healing ... #Stages #Orthopedics
Acute Compartment Syndrome
 • Crush injuries, burns, circumferential constriction to limbs (each containing facially divided muscle
Acute Compartment ... bleeding tendency/fracture ... compartment pressure #Acute ... pathophysiology #orthopedics
Adhesive Capsulitis (Frozen Shoulder) - Pathogenesis and Clinical Findings

 • Primary (Idiopathic): Unknown etiology, but associated
, humeral head fracture ... post-inflammatory healing ... post-inflammatory tissue healing ... diagnosis #symptoms #signs
Anorexia Nervosa: Signs and Symptoms
Binge/Purge Subtype - Recurrent (once per week) episodes of binge-eating or purging,
Anorexia Nervosa: Signs ... episodes of binge-eating ... psychological/behavioral features ... irritability #AnorexiaNervosa ... pathophysiology #diagnosis #signs
Anorexia Nervosa: Complications
CARDIAC ABNORMALITIES
 - Functional: Low BP, Sinus bradycardia, prolonged QT interval
 - Structural: Reduced
increased risk of fracture ... warmth) GENERAL FEATURES ... binge-purge subtype #AnorexiaNervosa ... pathophysiology #diagnosis #signs
Paget’s Disease: Complications
Abnormal Osteoclasts cause excessive bone turnover -> Incr bone resorption, Incr (abnormal) bone formation

MSK
-> Pathologic fractures ... -> Conductive hearing ... pathophysiology #diagnosis #signs