The Calgary Guide to Understanding Disease @TheCalgaryGuide
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Account created for The Calgary Guide to Understanding Disease - Linking pathophysiology to clinical presentation - http://calgaryguide.ucalgary.ca/
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Acquired Disorders of Reduced Bone Strength: Pathogenesis
 • Hyperparathyroidism
 • Vitamin D deficiency
 • Malabsorption syndromes
Diabetes • Other causes ... Acquired #Disorders #BoneStrength ... #pathophysiology ... #differential # ... diagnosis #osteoporosis
Subtrochanteric Femur Fracture: Pathogenesis and clinical findings
 • Subtrochanteric region spans 5 cm distally from the
fractures in elderly Causes ... young people) • Osteoporosis ... Fractures #msk #orthopedics ... #diagnosis #differential ... #causes #pathophysiology
Systemic Lupus Erythematosus (SLE): Musculoskeletal Manifestations

 • Immune Complex Deposition
    - Arthralgia, Arthritis
Myopathy (Also caused ... Normal CK • Osteoporosis ... Complications #pathophysiology ... #signs #symptoms ... #diagnosis
Chronic Hypertensive Retinopathy: Pathogenesis and clinical findings

Ophthalmic Artery Hypertension
Stage 1: Mild/vasoconstrictive
 • Acute and chronic vasospasm
Hypertension Stage ... -> AV nicking Stage ... #Retinopathy #pathophysiology ... ophthalmology #diagnosis ... #signs #symptoms
Adhesive Capsulitis (Frozen Shoulder) - Pathogenesis and Clinical Findings

 • Primary (Idiopathic): Unknown etiology, but associated
a stroke that caused ... side) Second Stage ... FrozenShoulder #pathophysiology ... #diagnosis #symptoms ... #signs #stages
Central Retinal Artery Occlusion: Pathogenesis and clinical findings
 • Inflammatory Disease: (i.e. GCA, SLE, GPA) ->
hypercoagulable state ... retinal edema caused ... Occlusion #CRAO #pathophysiology ... ophthalmology #diagnosis ... #signs #symptoms
Mastoiditis: Pathogenesis and clinical findings

Acute or Chronic Otitis Media -> 
Stage 1: Hyperemeia of the mastoid
Otitis Media -> Stage ... hearing loss, nausea ... #Mastoiditis #pathophysiology ... #signs #symptoms ... #diagnosis #otology
Fracture Healing (and disruptors of this process)
Inflammatory Stage (0-7d)
 • Fracture disrupts local blood vessels ->
Inflammatory Stage ... Fluoroquinolones - Causes ... #Orthopedics #msk ... #Staging #pathophysiology ... #diagnosis #disruptors
Paget’s Disease: Complications
Abnormal Osteoclasts cause excessive bone turnover -> Incr bone resorption, Incr (abnormal) bone formation

MSK
Abnormal Osteoclasts cause ... Nephrolithiasis (Kidney Stones ... PagetsDisease #pathophysiology ... #diagnosis #signs ... #symptoms #complications
Conduct Disorder (CD): Pathogenesis and clinical findings
 - Must have >3 symptoms present in the past
physical fights • Uses ... weapon that can cause ... lengthy period • Stays ... BehavioralDisorder #Pathophysiology ... #diagnosis #symptoms