The Calgary Guide to Understanding Disease @TheCalgaryGuide
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Account created for The Calgary Guide to Understanding Disease - Linking pathophysiology to clinical presentation - http://calgaryguide.ucalgary.ca/
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Stress Fracture: Pathogenesis and clinical findings
Abnormal biomechanics, Repetitive impact activities
=> Repetitive subthreshold mechanical loading
=> Bone strain
=>
Stress Fracture: ... => Microscopic fractures ... => Fracture propagation ... loading Stress Fracture ... StressFractures #msk #orthopedics
Subtrochanteric Femur Fracture: Pathogenesis and clinical findings
 • Subtrochanteric region spans 5 cm distally from the
Subtrochanteric Femur Fracture ... low energy fall fractures ... Atypical femur fracture ... #msk #orthopedics ... #diagnosis #differential
Classification of Pelvic Ring Fractures: Mechanisms, Clinical Features and Complications
 • Anterior Posterior Compression (APC) -
of Pelvic Ring Fractures ... bilateral rami fractures ... Grade 2 - Rami fracture ... #PelvicRing #Fractures ... Grades #Grading #Orthopedics
Open Fractures: Mechanisms, Clinical Features and Complications
Gustilo-Anderson Classification:
 • Type I
   - Wound <
Open Fractures: ... Mechanisms, Clinical Features ... Classification #Open #Fractures ... Complications #MSK #Orthopedics
Femoral Head Fracture: Pathogenesis and clinical findings
 • Posterior hip dislocation -> Impaction force from femoral
Femoral Head Fracture ... • Non-union of fracture ... #FemoralHead #Fractures ... signs #symptoms #orthopedics
Major Depressive Disorder (MDD): Pathogenesis and Clinical Findings

Symptoms (included in DSM 5 criteria) - Present during
with psychotic features ... with psychotic features ... Signs #Symptoms #Psychiatry
Acute Compartment Syndrome
 • Crush injuries, burns, circumferential constriction to limbs (each containing facially divided muscle
bleeding tendency/fracture ... pathophysiology #orthopedics
Medical Conditions Causing Mania or Mania-Like Episodes: Pathogenesis
 • Bipolar Disorder -> Combination of individual, genetic,
Secondary #Causes #Differential ... Pathophysiology #Psychiatry
Anorexia Nervosa: Complications
CARDIAC ABNORMALITIES
 - Functional: Low BP, Sinus bradycardia, prolonged QT interval
 - Structural: Reduced
increased risk of fracture ... warmth) GENERAL FEATURES ... mortality rates of all psychiatric ... signs #symptoms #psychiatry
Fracture Healing (and disruptors of this process)
Inflammatory Stage (0-7d)
 • Fracture disrupts local blood vessels ->
Fracture Healing ... Stage (0-7d) • Fracture ... chondrocytes at fracture ... > bridging the fracture ... #Stages #Orthopedics