The Calgary Guide to Understanding Disease @TheCalgaryGuide
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Acute Compartment Syndrome
 • Crush injuries, burns, circumferential constriction to limbs (each containing facially divided muscle
Acute Compartment ... compartment pressure #Acute ... CompartmentSyndrome #ACS ... #pathophysiology ... #orthopedics
Fracture Healing (and disruptors of this process)
Inflammatory Stage (0-7d)
 • Fracture disrupts local blood vessels ->
(and disruptors ... ) • Fracture disrupts ... #Stages #Orthopedics ... #msk #Staging #pathophysiology ... #diagnosis #disruptors
Humoral Immunity - Pathogenesis and Clinical Findings
Antigens (Ag) are produced from pathogens (bacteria, viruses, fungi, parasites)
such as peptides ... Ags tagged with ... Opsonization: Abs ... coat pathogens, helping ... Humoral #Immunity #pathophysiology
Low Ankle Sprain: Pathomechanics and Clinical Findings

Grading Ligament Sprains
l: Minimal ligament disruption, mild swelling & tenderness,
ligament substance leading ... ligament substance leading ... #Sports #MSK #orthopedics ... Grades #Diagnosis #pathophysiology
Femoral Head Fracture: Pathogenesis and clinical findings
 • Posterior hip dislocation -> Impaction force from femoral
• Avulsion or shearing ... msk #diagnosis #pathophysiology ... signs #symptoms #orthopedics
Type I Hypersensitivity: Pathogenesis and clinical findings
Definition: Production of lgE Antibodies that bind to harmless allergens
degranulation, leading ... recognizes allergen as ... Allergen-specific lgE Abs ... Complications: • Acute ... Allergy #Immunology #pathophysiology
First Generation Anti-Psychotics: Mechanisms and Side Effects
Typical/Conventional Anti-Psychotics - Examples: Haloperidol, Chlorpromazine

ACh M1 antagonist - Block
Chlorpromazine ACh ... Block action of ACh ... bradykinesia/akinesia • Acute ... • Akathisia - Feeling
Anterior Shoulder Dislocation: Pathogenesis, clinical, and radiographic findings

Trauma, Fall on, outstretched arm, Overhead throwing => Abduction
to glenoid -> Acute ... symptoms #msk #orthopedics ... #pathophysiology
Achilles Tendon Rupture - Pathogenesis and clinical findings
 • The Achilles tendon is 15cm long in
warriors") • Acute ... signs #symptoms #pathophysiology ... #msk #orthopedics
Acute Spinal Cord Injuries: Pathogenesis and clinical findings
 • Anterior Cord Syndrome -> Anterior spinal artery
Acute Spinal Cord ... weakness and #Acute ... Syndromes #diagnosis #pathophysiology ... symptoms #msk #orthopedics