The Calgary Guide to Understanding Disease @TheCalgaryGuide
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diagnosis symptoms pituitary anaphylaxis hypersensitivityreaction msk orthopedics achilles complications gh glftap growthhormone injury macroadenoma management masseffects mnemonic neurology prolactin rheumaticfever
Type I Hypersensitivity: Pathogenesis and clinical findings Definition: Production of lgE Antibodies that bind to harmless allergens
: Pre-formed lgE ... binds allergen, ... ": release the pro-inflammatory ... Complications: • Acute ... #Immunology #pathophysiology
Feedback Loop: Prolactin (PRL) • PRL levels exhibit diurnal, menstrual, and age-related variation • TRH has
Loop: Prolactin (PRL ... ) • PRL levels ... stimulatory effect on PRL ... #FeedbackLoop # ... endocrinology #pathophysiology
Anaphylaxis: Signs and Symptoms Anaphylaxis: when any egg of three conditions is met: 1. Acute onset of skin/mucosal
Acute onset of skin ... exposure to known allergen ... symptoms in the acute ... #Anaphylaxis #pathophysiology ... #immunology #diagnosis
Feedback Loop: Growth Hormone (GH) Growth Hormone: • Liver -> GHR activates JAK-STAT pathway -> Incr IGF1
activates lipolysis Signs ... GrowthHormone #GH #FeedbackLoop ... #endocrinology ... #pathophysiology
Type II Hypersensitivity: Pathogenesis and clinical findings Definition: When antigens bind to the body's cell surfaces, forming
with specific pre-formed ... HypersensitivityReaction #Allergy ... #Immunology #pathophysiology
Anaphylaxis: Treatments (Acute) Additional Info: • IV steroids may be considered for prevention of late phase reactions.
Anaphylaxis: Treatments (Acute ... provided, as well as allergy ... Treatments #Management #pathophysiology ... #immunology
Acute Rheumatic Fever: Pathogenesis and Clinical Findings Delayed autoimmune reaction -> Molecular mimicry -> GAS antigen cross-reacts with host ->
Acute Rheumatic ... injury -> Prolonged PR ... , Carditis #Acute ... RheumaticFever #pathophysiology ... #diagnosis #signs
Achilles Tendon Rupture - Pathogenesis and clinical findings • The Achilles tendon is 15cm long in
warriors") • Acute ... with no specific pre-determined ... etiology Signs ... TendonRupture #diagnosis #signs ... #symptoms #pathophysiology
Pituitary Mass Effects - Pathogenesis and Clinical Findings • Pituitary turnors are almost always a benign
FSH, TSH, ACTH, PRL ... Signs / Symptoms ... #SideEffects #endocrinology ... mnemonic #GLFTAP #pathophysiology
Acute Spinal Cord Injuries: Pathogenesis and clinical findings • Anterior Cord Syndrome -> Anterior spinal artery
Acute Spinal Cord ... compression, often with pre-existing ... weakness and #Acute ... Syndromes #diagnosis #pathophysiology ... #signs #symptoms
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