The Calgary Guide to Understanding Disease @TheCalgaryGuide
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Account created for The Calgary Guide to Understanding Disease - Linking pathophysiology to clinical presentation - http://calgaryguide.ucalgary.ca/
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diagnosis signs lupus sle temporal erythematosus giantcell msk pediatrics peds systemic 21hydroxylasedeficiency 21ohd cranialarteritis criteria disease endocrinology extraarticular femoralhead fractures
Giant Cell (Temporal) Arteritis: Pathogenesis and investigations Risk Factors: - Unclear environmental triggers (may be viral, not
Cell (Temporal) Arteritis ... not proven) - Genetic ... old; F>M Signs/Symptoms ... #Pathophysiology ... #Vasculitis
Giant Cell (Temporal) Arteritis: Clinical findings and Complications Signs/Symptoms: - Headache (usually constant, superimposed by waves
Cell (Temporal) Arteritis ... Clinical findings and Complications ... GiantCell #Temporal #Arteritis ... #Complications ... #diagnosis #Vasculitis
Systemic Lupus Erythematosus: Gastrointestinal Manifestations - Thrombosis of vessels in the pancreas, Vasculitis -> Acute Pancreatitis
the pancreas, Vasculitis ... Gastrointestinal #Complications ... #pathophysiology ... #signs #symptoms
IgA Vasculitis – Henoch Scholein Purpura: Pathogenesis and Clinical Findings - Infectious Agents - 50% have
IgA Vasculitis – ... predisposition - Various genetic ... Arthralgia's (common), arthritis ... HenochScholeinPurpura #Pathophysiology ... Diagnosis #Signs #Symptoms
Systemic Lupus Erythematosus (SLE): Musculoskeletal Manifestations • Immune Complex Deposition - Arthralgia, Arthritis
- Arthralgia, Arthritis ... Musculoskeletal #Complications ... #pathophysiology ... #signs #symptoms
Prader-Willi Syndrome: Pathogenesis and clinical findings • Maternal uniparental disomy: inheriting 2 copies of maternal chromosome
Syndrome Signs/Symptoms ... /Complications: ... PraderWilli #Syndrome #genetics ... #pathophysiology
Femoral Head Fracture: Pathogenesis and clinical findings • Posterior hip dislocation -> Impaction force from femoral
lateral hip Signs/Symptoms ... /Complications: ... weight-bear • Arthritic ... msk #diagnosis #pathophysiology ... #signs #symptoms
Kawasaki Disease: Clinical Findings Diagnostic Criteria - Fever and 4/5 of the following: • Conjunctivitis • Polymorphous
/Complications: ... - Coronary Arteritis ... Criteria #Diagnosis #Pathophysiology ... #Signs #Symptoms ... #Vasculitis
21-Hydroxylase Deficiency (21-OHD): Pathogenesis and Clinical Findings Autosomal recessive mutation in CYP21A2 coding for the enzyme 21-OHase
Signs/Symptoms/Complications ... #21HydroxylaseDeficiency #21OHD #pathophysiology ... #genetics #endocrinology
Lupus (SLE): Mucocutaneous Manifestations • Langerhan cells and keratinocytes release cytokines -> localized inflammatory response ->
Livedo Reticularis, Vasculitis ... Manifestations #pathophysiology ... diagnosis #signs #symptoms ... #complications
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