The Calgary Guide to Understanding Disease @TheCalgaryGuide
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Chronic Hypertensive Retinopathy: Pathogenesis and clinical findings

Ophthalmic Artery Hypertension
Stage 1: Mild/vasoconstrictive
 • Acute and chronic vasospasm
Chronic Hypertensive ... Retinopathy: Pathogenesis ... #Hypertensive #Retinopathy ... #pathophysiology ... #ophthalmology
Diabetic Retinopathy: Pathogenesis and clinical findings

Mild Non-proliferative DR
 • Outpouchings of the weakened capillary walls or
Diabetic Retinopathy ... #Diabetic #Retinopathy ... #Diabetes #ophthalmology ... complications #pathophysiology
Type IV Hypersensitivity: Pathogenesis and clinical findings
Definition: Unique because it is entirely T-Cell mediated; exposure to
Stevens-Johnson Syndrome ... HypersensitivityReaction #Allergy #Immunology ... #pathophysiology
Xeropthalmia: Pathogenesis and Ocular Manifestations

Decr Visual pigment -> Keratinization, thickening & non-wetting of the conjunctiva
focal melting) -> Retinopathy ... #Xeropthalmia #pathophysiology ... #ophthalmology
Fecal Incontinence - Pathogenesis and Complications
Continence mechanisms are impaired
 • Local neuronal damage
 • External and
proctitis) • Chronic ... irritable bowel syndrome ... laxatives • Chronic ... Incontinence #geriatrics #pathophysiology
Retinopathy of Prematurity: Pathogenesis and clinical findings
Increased metabolic demand of growing eye
-> Excessive VEGF production ->
Retinopathy of Prematurity ... detachment #Retinopathy ... peds #pediatrics #pathophysiology ... #ophthalmology
Keratoconus: Pathogenesis and Clinical Findings
Genetics
 • Family history of keratoconus
 • Ehlers-Danlos syndrome
 • Down, Turner,
Ehlers-Danlos syndrome ... Turner, Marfan syndromes ... #Keratoconus #pathophysiology ... #ophthalmology
Acquired Disorders of Reduced Bone Strength: Pathogenesis
 • Hyperparathyroidism
 • Vitamin D deficiency
 • Malabsorption syndromes
Malabsorption syndromes ... • Chronic metabolic ... #BoneStrength #pathophysiology
Chronic Exertional Compartment Syndrome (CECS)
 • Diagnosis Of CECS requires patient to undergo the same exertional
Chronic Exertional ... Compartment Syndrome ... CompartmentSyndrome #CECS #pathophysiology
Chemical Eye Injury: Pathogenesis and clinical findings
Exogenous chemical to the eye and/or adnexa
 • Ammonia, sodium
hydrofluoric, acetic, chromic ... #Eye #Ocular #opthalmology ... #pathophysiology