The Calgary Guide to Understanding Disease @TheCalgaryGuide
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Account created for The Calgary Guide to Understanding Disease - Linking pathophysiology to clinical presentation - http://calgaryguide.ucalgary.ca/
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Systemic Lupus Erythematosus (SLE): Musculoskeletal Manifestations

 • Immune Complex Deposition
    - Arthralgia, Arthritis
Erythematosus (SLE ... Erythematosus #SLE ... #MSK #Musculoskeletal ... Complications #pathophysiology ... signs #symptoms #diagnosis
Lupus (SLE): Mucocutaneous Manifestations

 • Langerhan cells and keratinocytes release cytokines -> localized inflammatory response ->
Lupus (SLE): Mucocutaneous ... with keratotic scaling ... Phenomenon #Lupus #SLE ... Manifestations #pathophysiology ... #diagnosis #signs
Meralgia paresthetica: Pathogenesis and Clinical Findings
Compression/injury of Lateral Femoral Cutaneous Nerve (LFCN) -> Meralgia paresthetica
 •
sensory • Before diagnosis ... , Stabbing) - ... MeralgiaParesthetica #MSK ... #pathophysiology ... #differential #diagnosis
Radiculopathy: Signs and Symptoms
 • Back/Neck Pain
 • Decr Range of motion
 • Abnormal posturing
 •
: -> Shooting, stabbing ... Radiculopathy #MSK ... #diagnosis #signs ... #symptoms #pathophysiology
Cauda Equina Syndrome
Causes:
 • Large lumbar degenerative disc herniation (central)
 • Severe lumbar spondylosis
 • Neoplasm
pain (shooting, stabbing ... CaudaEquina #Syndrome #MSK ... #pathophysiology ... #diagnosis #symptoms
Classification of Pelvic Ring Fractures: Mechanisms, Clinical Features and Complications
 • Anterior Posterior Compression (APC) -
Anterior Sl diastasis ... posterior through Sl ... #Orthopedics #MSK ... #diagnosis #complications ... #pathophysiology
Adhesive Capsulitis (Frozen Shoulder) - Pathogenesis and Clinical Findings

 • Primary (Idiopathic): Unknown etiology, but associated
FrozenShoulder #pathophysiology ... #diagnosis #symptoms ... signs #stages #staging ... #msk
Diffuse Systemic Sclerosis (Scleroderma)
 - Pulmonary Fibrosis -> Crackles, Abnormal CXR
 - Pulmonary Hypertension, Right Heart
Renal Failure - Mask ... (i.e. a "purse-string ... #Scleroderma #pathophysiology ... signs #symptoms #diagnosis
Fracture Healing (and disruptors of this process)
Inflammatory Stage (0-7d)
 • Fracture disrupts local blood vessels ->
#Orthopedics #msk ... #Staging #pathophysiology ... #diagnosis #disruptors