The Calgary Guide to Understanding Disease @TheCalgaryGuide
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Account created for The Calgary Guide to Understanding Disease - Linking pathophysiology to clinical presentation - http://calgaryguide.ucalgary.ca/
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pathophysiology diagnosis vasculitis pediatrics giantcell syndrome temporal 21hydroxylasedeficiency 21ohd achilles acute anterior bakerscyst caudaequina causes criteria disease dislocation endocrinology erythematosus
Femoral Head Fracture: Pathogenesis and clinical findings • Posterior hip dislocation -> Impaction force from femoral
onto lateral hip Signs ... /Symptoms/Complications ... weight-bear • Arthritic ... FemoralHead #Fractures #msk ... #symptoms #orthopedics
Giant Cell (Temporal) Arteritis: Clinical findings and Complications Signs/Symptoms: - Headache (usually constant, superimposed by waves
Cell (Temporal) Arteritis ... Clinical findings and Complications ... Signs/Symptoms ... #Complications ... #Signs #Symptoms
Systemic Lupus Erythematosus (SLE): Musculoskeletal Manifestations • Immune Complex Deposition - Arthralgia, Arthritis
- Arthralgia, Arthritis ... Erythematosus #SLE #MSK ... Musculoskeletal #Complications ... pathophysiology #signs ... #symptoms #diagnosis
Giant Cell (Temporal) Arteritis: Pathogenesis and investigations Risk Factors: - Unclear environmental triggers (may be viral, not
Cell (Temporal) Arteritis ... not proven) - Genetic ... yrs old; F>M Signs ... /Symptoms: - Fever ... #Symptoms #Vasculitis
Prader-Willi Syndrome: Pathogenesis and clinical findings • Maternal uniparental disomy: inheriting 2 copies of maternal chromosome
Prader-Willi Syndrome Signs ... /Symptoms/Complications ... PraderWilli #Syndrome #genetics ... pathophysiology #peds
Achilles Tendon Rupture - Pathogenesis and clinical findings • The Achilles tendon is 15cm long in
pre-determined etiology Signs ... /Symptoms/Complications ... TendonRupture #diagnosis #signs ... #symptoms #pathophysiology ... #msk #orthopedics
Stress Fracture: Pathogenesis and clinical findings Abnormal biomechanics, Repetitive impact activities => Repetitive subthreshold mechanical loading => Bone strain =>
StressFractures #msk ... #orthopedics #pathophysiology ... #symptoms #signs
Cauda Equina Syndrome Causes: • Large lumbar degenerative disc herniation (central) • Severe lumbar spondylosis • Neoplasm
lumbar spine Signs ... / Symptoms / Complications ... CaudaEquina #Syndrome #MSK ... pathophysiology #diagnosis #symptoms ... #signs
21-Hydroxylase Deficiency (21-OHD): Pathogenesis and Clinical Findings Autosomal recessive mutation in CYP21A2 coding for the enzyme 21-OHase
Signs/Symptoms/Complications ... pathophysiology #genetics ... endocrinology #peds
Keratoconus: Pathogenesis and Clinical Findings Genetics • Family history of keratoconus • Ehlers-Danlos syndrome • Down, Turner,
Clinical Findings Genetics ... > Keratoconus Signs ... / Symptoms / Complications ... Ring • Munson's sign ... • Rizutti's Sign
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